New drug trial for tough bone cancer halted early
NCT ID NCT03514407
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tested an experimental drug called INCB059872 in 25 people with Ewing sarcoma that had returned or stopped responding to standard treatments. The goal was to check the drug's safety and see if it could shrink tumors. The study was terminated early, so full results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- INCB059872 (an experimental drug taken by mouth every other day)
- What this could lead to
- If it works, this could point toward a new treatment option for people with Ewing sarcoma that has come back or not responded to standard therapy.
- What could go wrong
- This is a very early (Phase 1) trial with only 25 participants, and it was terminated early, so results are limited. The drug may not shrink tumors or may cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Columbia University Medical Center
New York, New York, 10032, United States
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Hospital Clínico San Carlos
Madrid, 28040, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Istituto Ortopedico Rizzoli
Bologna, 40136, Italy
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Mayo Clinic Jacksonville - PPDS
Jacksonville, Florida, 32224, United States
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Ospedale Pediatrico Bambino Gesu IRCCS
Rome, 00146, Italy
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Policlinico Sant'orsola-Malpighi
Bologna, 40138, Italy
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
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UCLA Jonsson Comprehensive Cancer
Los Angeles, California, 90095, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.