New drug INCA036978 enters human testing for rare blood cancers

NCT ID NCT07441694

Recruiting now Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This early-stage study tests an experimental drug, INCA036978, in about 218 adults with myeloproliferative neoplasms (a group of blood cancers). The main goal is to check the drug's safety and find the best dose, either alone or with standard treatment. Participants must have a life expectancy over 6 months and cannot have other recent cancers or serious infections.

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Conditions

The condition(s) this trial relates to.

acquired polycythemia vera essential thrombocythemia myelofibrosis Myeloproliferative Disorders myeloproliferative neoplasm primary myelofibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYELOPROLIFERATIVE NEOPLASMS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

A. Gemelli University Hospital, Catholic University of the Sacred Heart
NOT_YET_RECRUITING

Roma, 00168, Italy
AZ DELTA
NOT_YET_RECRUITING

Roeselare, 08800, Belgium
Aou Policlinico S. Orsola-Malpighi
NOT_YET_RECRUITING

Bologna, 40138, Italy
Azienda Sanitaria Universitaria Friuli Centrale Asu Fc
NOT_YET_RECRUITING

Udine, 33100, Italy
Centre Hospitalier Universitaire (Chu) de Liege
NOT_YET_RECRUITING

Liège, 04000, Belgium
Charite Universitaetsmedizin Berlin - Campus Charite Mitte
NOT_YET_RECRUITING

Berlin, 10117, Germany
City of Hope-Lennar Foundation Cancer Center
NOT_YET_RECRUITING

Irvine, California, 92618, United States
Cleveland Clinic
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Concord General Repatriation Hospital
RECRUITING

Concord, New South Wales, 02139, Australia
Duke University Medical Center, Department of Hematologic Malignancies and Cellular Therapy
NOT_YET_RECRUITING

Durham, North Carolina, 27705, United States
Ehime University Hospital
NOT_YET_RECRUITING

Toon, Ehime, 791-0204, Japan
Epworth Health Care
RECRUITING

East Melbourne, Victoria, 03002, Australia
Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico
NOT_YET_RECRUITING

Milan, 20122, Italy
Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust
NOT_YET_RECRUITING

London, SE1 9RT, United Kingdom
Hospital Saint Louis
NOT_YET_RECRUITING

Paris, 75010, France
Hospital Universitari Germans Trias I Pujol
NOT_YET_RECRUITING

Badalona, 08916, Spain
Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING

Madrid, 28041, Spain
Hospital Universitario de Gran Canaria Dr. Negrin
NOT_YET_RECRUITING

Las Palmas de Gran Canaria, 35010, Spain
Huntsman Cancer Institute
NOT_YET_RECRUITING

Salt Lake City, Utah, 84112, United States
Icon Cancer Centre
RECRUITING

Auchenflower, Queensland, 04066, Australia
Institut Bergonie
NOT_YET_RECRUITING

Bordeaux, 33076, France
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94805, France
John Hopkins Hospital
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
Levine Cancer Institute
NOT_YET_RECRUITING

Charlotte, North Carolina, 28204, United States
Linear Clinical Research
RECRUITING

Nedlands, Western Australia, 06009, Australia
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
McGill University Jewish General Hospital
NOT_YET_RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Medical College of Wisconsin
NOT_YET_RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center
NOT_YET_RECRUITING

New York, New York, 10021, United States
Moffitt Cancer Center
NOT_YET_RECRUITING

Tampa, Florida, 33612, United States
Mount Sinai School of Medicine
NOT_YET_RECRUITING

New York, New York, 10029, United States
National Cancer Center Hospital East
NOT_YET_RECRUITING

Kashiwa Chiba, 277-0882, Japan
Nottingham University Hospitals
NOT_YET_RECRUITING

Nottingham, NG5 1PB, United Kingdom
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Princess Margaret Cancer Center
NOT_YET_RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Royal North Shore Hospital
RECRUITING

St Leonards, New South Wales, 02065, Australia
Seoul National University Hospital
NOT_YET_RECRUITING

Jongno-gu, Seoul, 03080, South Korea
The Catholic University of Korea Seoul St. Mary'S Hospital
NOT_YET_RECRUITING

Seocho-gu, Seoul, 06591, South Korea
Tristar Bmt/Tcto
RECRUITING

Nashville, Tennessee, 37203, United States
UCLA Medical Hematology & Oncology
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
Universitatklinikum Freiburg
NOT_YET_RECRUITING

Freiburg im Breisgau, 79106, Germany
Universitatsklinikum Halle (Saale)
NOT_YET_RECRUITING

Halle, 06120, Germany
Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii
NOT_YET_RECRUITING

Mainz, 55131, Germany
University Medical Center Rwth Aachen
NOT_YET_RECRUITING

Aachen, D-52074, Germany
University of Alabama At Birmingham
NOT_YET_RECRUITING

Birmingham, Alabama, 35233, United States
University of Miami
NOT_YET_RECRUITING

Miami, Florida, 33136, United States
University of North Carolina At Chapel Hill
NOT_YET_RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Oxford
NOT_YET_RECRUITING

Oxford, OX3 7LE, United Kingdom
University of Texas M. D. Anderson Cancer Center
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Usc Norris Comprehensive Cancer Center
NOT_YET_RECRUITING

Los Angeles, California, 90033, United States
Washington University School of Medicine
NOT_YET_RECRUITING

St Louis, Missouri, 63108, United States
Weill Cornell Medicine
NOT_YET_RECRUITING

New York, New York, 10065, United States
Winship Cancer Institute of Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Yale Cancer Center
NOT_YET_RECRUITING

New Haven, Connecticut, 06510, United States

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