Prenatal steroid for CAH: safe for the brain? new study investigates
NCT ID NCT02795871
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study evaluates the long-term cognitive development of children who were exposed to dexamethasone (a steroid) while in the womb because they were at risk for congenital adrenal hyperplasia (CAH). The goal is to see if the drug causes any thinking or memory problems. Researchers will compare children with and without CAH who were or were not exposed to the drug, using IQ and memory tests.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dexamethasone (a steroid given during pregnancy)
What this could lead to
If results show no harm, it could support the cautious use of prenatal dexamethasone to prevent genital virilization in girls with CAH, reducing the need for surgery.
What could go wrong
This is an observational follow-up study, not a new treatment trial. Previous studies have shown conflicting results on cognitive risks, and the small sample size may limit conclusions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Groupement Hospitalier Est - Laboratoire d'endocrinologie moléculaire et maladies rares - Centre de biologie et de pathologie Est. 59 boulevard Pinel
Bron, 69677, France
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Service d'endocrinologie pédiatrique, CHRU de Lille
Lille, France
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Service d'endocrinologie pédiatrique, CHU de Besançon
Besançon, France
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Service d'endocrinologie pédiatrique, CHU de Bordeaux
Bordeaux, France
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Service d'endocrinologie pédiatrique, CHU de Grenoble
Grenoble, France
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Service d'endocrinologie pédiatrique, CHU de Nantes
Nantes, France
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Service d'endocrinologie pédiatrique, CHU de Nice
Nice, France
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Service d'endocrinologie pédiatrique, CHU de Reims
Reims, France
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Service d'endocrinologie pédiatrique, Hopital de la Timone, APHM
Marseille, France
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Service d'endocrinologie pédiatrique, Hôpital Armand Trousseau, AP-HP
Paris, France