Gene test could guide leukemia treatment after chemo
NCT ID NCT02756962
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether checking for leftover leukemia-related gene mutations after initial chemotherapy can help predict relapse and survival in adults with acute myeloid leukemia (AML). Researchers will follow 107 patients aged 18-60 who are in remission after chemo. Those whose mutations have cleared will receive standard consolidation chemo, while those with persistent mutations may get a stem cell transplant. The goal is to see if this genetic approach improves survival compared to historical averages.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cytarabine (chemotherapy) and allogeneic stem cell transplant
What this could lead to
If successful, this could help doctors better predict which AML patients need more aggressive treatment after initial chemotherapy, potentially improving survival rates.
What could go wrong
This is a Phase 2 study with only 107 participants, so results may not apply to all patients. The approach relies on genetic testing that may not capture all mutations, and the benefit of changing treatment based on results is not yet proven.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Florida
Gainesville, Florida, 32608, United States
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University of Rochester
Rochester, New York, 14642, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States