New hope for hard-to-treat breast cancer: immune-boosting combos tested

NCT ID NCT03971409

First seen Apr 20, 2026 · Last updated May 09, 2026 · Updated 2 times

Summary

This study tests whether combining an immunotherapy drug (avelumab) with other targeted drugs can shrink or control advanced triple-negative breast cancer that has spread or come back. About 145 adults with stage IV or inoperable breast cancer are taking part. The goal is to see if these combinations work better than standard treatments.

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Contacts and locations

Locations

  • Abramson Cancer Center, University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Duke Cancer Institute

    Durham, North Carolina, 27710, United States

  • Georgetown University

    Washington D.C., District of Columbia, 20057, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • O'Neal Comprehensive Cancer Center

    Birmingham, Alabama, 35294, United States

  • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University

    Baltimore, Maryland, 21218, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • University of California, San Francisco

    San Francisco, California, 94143, United States

  • University of Chicago Medicine Comprehensive Cancer Center

    Evergreen Park, Illinois, 60805, United States

  • Vanderbilt University Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.