New combo therapy for metastatic tumors shows early promise but trial halted

NCT ID NCT05491317

First seen Nov 01, 2025 · Last updated May 03, 2026 · Updated 26 times

Summary

This early-stage trial tested a new drug (GEN1042) combined with radiation, with or without another immunotherapy (pembrolizumab), in 13 adults with metastatic solid tumors that had no standard treatment options. The goal was to see if the combination was safe and could shrink tumors, including those not directly treated with radiation. The study was terminated early, so results are limited.

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Contacts and locations

Locations

  • Centre Leon Berard

    Lyon, 69008, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

Conditions

Explore the condition pages connected to this study.