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Can a Blood-Based filler beat bone grafts for tooth implants?

NCT ID NCT07797452

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 09, 2026 · Updated 3 times

Summary

This trial tests whether filling the gap around a new lower molar implant with a bone graft material, a blood-derived product called e-PRF, or nothing at all leads to better healing. Researchers will measure changes in gum and bone using 3D scans and check implant stability. The study includes 30 people who need a lower molar extracted and replaced with an implant. The goal is to find which approach preserves tissue best around the implant.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Xenograft particulates or e-PRF (patient-derived platelet-rich fibrin) placed in the gap around an immediate dental implant
What this could lead to
If one grafting material works better, dentists may have a clearer choice for preserving bone and gum around immediate molar implants, improving long-term outcomes.
What could go wrong
This is a small, early-stage trial with 30 participants, so results may not apply to everyone. Grafting materials can sometimes cause inflammation or healing issues, and the best option may vary by patient.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Feb 2025

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Any partially dentate patients with non-restorable mandibular molar requiring dental extraction. * Extraction sockets with intact bony walls and interradicular bone. * Jumping gap more than 2mm. Exclusion Criteria: * Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site impaired the immediate implant placement. * Heavy smokers (≥ pack per day) * Pregnancy. * Patients with systemic diseases that absolutely contraindicate implant placement or para-functional habits (bruxism or clenching). * Patients with poor oral hygiene or aggressive periodontal disease.

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Conditions

The condition(s) this trial relates to.

Tooth Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Immediate implant placement in mandibular molar extraction sockets Jumping gap Tooth loss and rehabillitation

Contacts and locations

Locations

  • Faculty of Dentistry, Mansoura University

    Al Mansurah, Egypt

More trials for these conditions

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