New immune drug IMA401 takes on Hard-to-Treat cancers
NCT ID NCT05359445
First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 26 times
Summary
This early-phase study tests a new drug called IMA401 in about 95 adults with advanced solid tumors (like lung or head/neck cancer) that came back or didn't respond to prior treatments. IMA401 is a special immune molecule that helps the body's T cells attack cancer cells. The study gives IMA401 alone or with another immune-boosting drug (pembrolizumab) to find the safest dose and see if it shrinks tumors. Participants must have a specific genetic marker (HLA type) and their tumor must produce certain proteins (MAGE-A4 or MAGE-A8).
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Charité Universitaetsmedizin Berlin KöR, Klinik fuer Haematologie und Onkologie
Berlin, 12203, Germany
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Goethe Universitaetsklinikum Frankfurt AöR, Medizinische Klinik II
Frankfurt am Main, Hesse, 60590, Germany
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Klinikum Chemnitz gGmbH, Klinik für Innere Medizin III
Chemnitz, Saxony, 09116, Germany
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Klinikum Nuernberg, Klinik fuer Innere Medizin 5, Abteilung Onkologie/Haematologie
Nuremberg, Bavaria, 90419, Germany
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Klinikum rechts der Isar der TU Muenchen AöR, Klinik und Poliklinik fuer Innere Medizin III
Munich, Bavaria, 81675, Germany
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Marien Hospital Duesseldorf GmbH, Klinik fuer Onkologie/Haematologie und Palliativmedizin
Düsseldorf, North Rhine-Westphalia, 40479, Germany
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Medizinische Hochschule Hannover, Klinik fuer Haematologie, Haemostaseologie, Onkologie und Stammzelltransplantation
Hanover, Lower Saxony, 30625, Germany
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Thoraxklinik Heidelberg gGmbH, Studienzentrum Thoraxonkologie
Heidelberg, Baden-Wurttemberg, 69126, Germany
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Universitaet Leipzig, Universitaeres Krebszentrum Leipzig (UCCL)
Leipzig, Saxony, 04103, Germany
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Universitaetsklinikum C. - G. - Carus Dresden, Technische Universitaet Dresden AöR, NCT/UCC Early Clinical Trial Unit
Dresden, Saxony, 01307, Germany
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Universitaetsklinikum Erlangen AöR, Interdisciplinary Clinical Trial Unit with ECTU
Erlangen, Bavaria, 91054, Germany
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Universitaetsklinikum Freiburg, Zentralklinikum, Klinik fuer Innere Medizin I
Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Universitaetsklinikum Heidelberg AöR, Nationales Zentrum fuer Tumorkrankheiten
Heidelberg, Baden-Wurttemberg, 69120, Germany
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Universitaetsklinikum Muenster AöR, Medizinische Klinik A
Münster, North Rhine-Westphalia, 48149, Germany
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Universitaetsklinikum Regensburg AöR, Klinik fuer Innere Medizin 3
Regensburg, Bavaria, 93053, Germany
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Universitaetsklinikum Schleswig- Holstein, Campus Kiel, Medizinische Klinik II Haematologie und Onkologie, Karl-Lennert Tumorzentrum
Kiel, Schleswig-Holstein, 24105, Germany
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Universitaetsklinikum Tuebingen AöR, Comprehensive Cancer Center Tuebingen
Tübingen, Baden-Wurttemberg, 72076, Germany
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Universitaetsklinikum Ulm AöR, ECTU-Early clinical Trials Unit Universitaetsklinikum Ulm Comprehensive Cancer Center Ulm_CCCU
Ulm, Baden-Wurttemberg, 89081, Germany
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Universitaetsklinikum Wuerzburg AöR, Interdisziplinaeres Studienzentrum mit ECTU
Würzburg, Bavaria, 97078, Germany
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Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, III. Medizinische Klinik
Mainz, Rhineland-Palatinate, 55131, Germany
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Universitätsklinikum Bonn AöR, Medizinische Klinik IIII
Bonn, North Rhine-Westphalia, 53127, Germany
Conditions
Explore the condition pages connected to this study.