New drug trial aims to halt silent kidney damage

NCT ID NCT06963827

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

Summary

This study is testing an investigational drug called mezagitamab to see if it can help adults with IgA nephropathy, a condition where the immune system damages the kidneys. The main goal is to see if the drug reduces protein in the urine and helps protect long-term kidney function better than a placebo. Participants will receive either the drug or a placebo for about six months, followed by observation, over two one-year cycles.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Academic Medical Research Institute
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Los Angeles, California, 90022, United States

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Affiliated Hospital of Nantong University
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Nantong, Jiangsu, 226001, China

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Ajou University Hospital-Primary Research Location
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Suwon, Gyeonggido, 16499, South Korea

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Akershus University Hospital
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Lorenskog, Akershus, 1478, Norway

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Amsterdam UMC - Locatie AMC (Academisch Medisch Centrum)
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Amsterdam, North Holland, 1105 AZ, Netherlands

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Beijing Tsinghua Changgung Hospital
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Changping, Beijing Municipality, 102218, China

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Bioresearch Partners
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Miami, Florida, 33127, United States

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Bioresearch Partners
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Pembroke Pines, Florida, 33029, United States

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Birmingham Heartlands Hospital
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Birmingham, United Kingdom

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Brookview Hills Research Associates, LLC
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Winston-Salem, North Carolina, 27103, United States

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CARE Institute - Boise Kidney
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Boise, Idaho, 83706, United States

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CHU Limoges Service de Nephrology
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Limoges, 87042, France

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CHU de Nantes
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Nantes, 44093, France

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CTR Oakwater, LLC
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Orlando, Florida, 32806, United States

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Centre Hospitalier Universitaire de Montpellier (CHU Montpellier) - Hopital Lapeyronie
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Montpellier, 34090, France

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Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
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Ciudad Autonoma de Buenos Aires, Buenos Aires, C1425AGC, Argentina

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China Medical University Hospital
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Taichung, Taiwan

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Clinica Privada Velez Sarsfield
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Córdoba, X5016, Argentina

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Clinical Research Consultants a JCCT Company
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Kansas City, Missouri, 64111, United States

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Core Research Group
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Milton, Queensland, Australia

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DCR - El Paso
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El Paso, Texas, 79902, United States

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DCR Columbus
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Columbus, Georgia, 31904, United States

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DCR Edina
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Edina, Minnesota, 55435, United States

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DCR Montgomery
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Montgomery, Alabama, 36117, United States

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DCR San Antonio
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San Antonio, Texas, 78251, United States

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Dallas Renal Group
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Dallas, Texas, 75230, United States

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Dokkyo Medical University Saitama Medical Center
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Koshigaya-shi, Saitama, 343-8555, Japan

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Elixia MKC
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Pontiac, Michigan, 48341, United States

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Elixia MNA
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City of Saint Peters, Missouri, 63376, United States

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Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
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Milan, 20100, Italy

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Fujita Health University Hospital
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Toyoake-shi, Aichi-ken, 470-1192, Japan

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Fukushima Medical University Hospital
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Fukushima, Fukushima, 960-1295, Japan

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Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
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Şahinbey, Gaziantep, 27310, Turkey (Türkiye)

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Guangdong General Hospital
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Guangzhou, Guangdong, 510080, China

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Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital
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London, Greater London, SE1 9RT, United Kingdom

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Haukeland Universitetssjukehus
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Bergen, 5021, Norway

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Hiroshima University Hospital
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Hiroshima, Hiroshima, 734-8551, Japan

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Hokkaido University Hospital
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Sapporo, Hokkaido, 060-8648, Japan

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Hospital Britanico de Buenos Aires
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Ciudad Autonoma Buenos Aires, 1280, Argentina

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Hospital Henri Mondor
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Créteil, Paris, 94000, France

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Hospital Sultan Idris Shah Serdang (Hospital Serdang)
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Kajang, Selangor, 43000, Malaysia

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Hospital Taiping
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Taiping, Perak, 34000, Malaysia

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Hospital Tengku Ampuan Afzan
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Kuantan, Pahang, 25100, Malaysia

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Hospital Tenon
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Paris, 75020, France

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Hospital Universitari Germans Trias i Pujol
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Badalona, Barcelona, 8915, Spain

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Hospital Universitario Virgen del Rocio - PPDS
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Seville, 41013, Spain

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Houston Methodist Research Institute - Department of Medicine
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Houston, Texas, 77030, United States

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Hull University Teaching Hospitals NHS Trust
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Hull, United Kingdom

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IRCCS Azienda Ospedaliero-Universitaria di Bologna
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Bologna, 40138, Italy

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IRCCS Ospedale Policlinico San Martino
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Genoa, 16132, Italy

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Ingham Nephrology & Hypertension, P.C.
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Lansing, Michigan, 48911, United States

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Istituto Maugeri IRCCS Pavia
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Pavia, 27100, Italy

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Japan Community Health care Organization Sendai Hospital
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Sendai, Miyagi, 981-3281, Japan

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Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
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Nagoya, Aichi-ken, 466-8650, Japan

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Johannes Kepler Universitat Linz, Universitatsklinik fur Innere 2
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Linz, 4040, Austria

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Juntendo University Hospital
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Bunkyo-ku, Tokyo, 113-8431, Japan

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Kaohsiung Medical University - Chung-Ho Memorial Hospital
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Kaohsiung City, 807, Taiwan

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Kasugai Municipal Hospital
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Kasugai-Shi, Aichi-ken, 486-8510, Japan

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Kent & Canterbury Hospital, Canterbury
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Canterbury, CT1 3PA, United Kingdom

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King's College Hospital
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London, WC2R 2LS, United Kingdom

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Kyushu University Hospital
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Fukuoka, Fukuoka, 812-8582, Japan

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Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-Kofuka
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Osaka, Osaka, 530-8480, Japan

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Medizinische Universitat Wien (Medical University of Vienna - Austria)
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Vienna, 1090, Austria

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Nara Medical University Hospital
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Kashihara-shi, Nara, 634-8522, Japan

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Nara Prefecture General Medical Center
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Nara, Nara, 630-8581, Japan

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National Hospital Organization Chiba Medical Center Chibahigashi National Hospital
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Chiba, Chiba, 260-8712, Japan

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National Taiwan University Hospital
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Zhongzheng, 100, Taiwan

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National University Hospital
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Singapore, Singapore

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Nemocnice AGEL Novy Jicin a.s
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Nový Jičín, Moravskoslezsk Kraj, 741 01, Czechia

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Nephrology Associates of Houston PLLC
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Katy, Texas, 77450, United States

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Northwest Louisiana Nephrology
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Shreveport, Louisiana, 71101, United States

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Nowy Szpital Sp Zo.o
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Gmina Świecie, 86-100, Poland

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Oita University Hospital
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Yufu-shi, Oita Prefecture, 879-5593, Japan

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Peking University First Hospital
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Beijing, Beijing Municipality, 100034, China

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Peking University Shenzhen Hospital
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Shenzhen, Guangdong, 518000, China

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Provecta Research Network
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Houston, Texas, 77054, United States

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Renal Medicine Linkoping University/ Linkoping University Hospital
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Linköping, Sweden

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Ruijin Hospital of Shanghai Jiaotong University School of Medicine
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Shanghai, Shanghai Municipality, 200025, China

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SCM Sp. z o.o.
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Krakow, 31-559, Poland

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Seoul National University Boramae Medical Center
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Seoul, 7061, South Korea

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Seoul National University Bundang Hospital
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Seongnam-si, Seongnam, 13620, South Korea

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Seoul National University Hospital
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Seoul, 3080, South Korea

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Shandong University - Qilu Hospital
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Jinan, Shandong, 250012, China

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Shanghai Jiao Tong University School of Medicine (SJTUSM) - Renji Hospital - Eastern Branch
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Shanghai, Shanghai Municipality, 200000, China

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Sheldon M. Chumir Health Centre
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Calgary, Alberta, T2R 0X7, Canada

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Shonan Kamakura General Hospital
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Kamakura-shi, Kanagawa, 247-8533, Japan

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Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
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Chengdu, Sichuan, 610072, China

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Singapore General Hospital
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Singapore, 169608, Singapore

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Sint Antonius ziekenhuis Utrecht/Nieuwegein
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Nieuwegein, 3435CM, Netherlands

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South Florida Research Institute
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Lauderdale Lakes, Florida, 33313-1607, United States

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St George's University Hospitals NHS Foundation Trust
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London, SW17 0QT, United Kingdom

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Stavanger Universitetssjukehus - Helse Stavanger HF
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Stavanger, Norway

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Sun Research Institute
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San Antonio, Texas, 78215, United States

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Sunway Medical Centre (SMC)
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Subang Jaya, Selangor, 47500, Malaysia

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Sykehuset I Vestfold
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Tønsberg, Vestfold, Norway

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Sykehuset Ostfold
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Grålum, 1714, Norway

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Taichung Veterans General Hospital
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Taichung, 40705, Taiwan

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Taipei Medical University Shuang Ho Hospital
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New Taipei City, Taiwan

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Tan Tock Seng Hospital
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Singapore, 308433, Singapore

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The First Affiliated Hospital of Baotou Medical College
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Baotou, Inner Mongolia, 14010, China

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The First Affiliated Hospital of Ningbo University
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Ningbo, Zhejiang, 315010, China

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The Second Affiliated Hospital, Zhejiang University, School of Medicine
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Hangzhou, Zhejiang, China

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The Second People's Hospital of Yibin
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Yibin, Sichuan, 644099, China

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The Third Xiangya Hospital of Central South University Yuelu District
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Changsha, Hunan, 410013, China

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The University of Hong Kong - Department of Medicine
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Hong Kong, Hong Kong Island, Hong Kong

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Thomas Jefferson University
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Philadelphia, Pennsylvania, 19107, United States

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Tokyo Medical University Hospital
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Shinjuku-Ku, Tokyo, 160-0023, Japan

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Toranomon Hospital Kajigaya
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Kawasaki-shi, Kanagawa, 213-8587, Japan

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Turgut Ozal Medical Center
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Malatya, Battalgazi, 44280, Turkey (Türkiye)

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UAB Nephrology Research Clinic at Paula Building
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Birmingham, Alabama, 35233-2110, United States

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Uniklinik RWTH Aachen
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Aachen, North Rhine-Westphalia, 52074, Germany

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Universidad de Navarra - Clinica Universidad de Navarra
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Pamplona, Navarre, 31008, Spain

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Universidad de Navarra - Clinica Universidad de Navarra
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Madrid, 28027, Spain

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Universitaetsklinikum Jena
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Jena, Thuringia, 7747, Germany

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Universitetssykehuset I Trondheim - St. Olavs Hospital - Nevroklinikken
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Trondheim, 7030, Norway

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Universiti Kebangsaan Malaysia (UKM) - Medical Centre (Pusat Perubatan) (Hospital Canselor Tuanku Muhriz (HCTM))
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Kuala Lumpur, Kuala Lumpur, 56000, Malaysia

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University Hospital Zurich
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Zurich, 8091, Switzerland

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University Medical Centre Ljubljana
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Ljubljana, 1000, Slovenia

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University of California Irvine
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Orange, California, 92868-3201, United States

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University of Yamanashi Hospital
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Chuo-shi, Yamanashi, 409-3898, Japan

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Utah Kidney Research Institute
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Salt Lake City, Utah, 84115, United States

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West China Hospital Sichuan University
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Chengdu, Sichuan, 610000, China

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West Virginia University
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Morgantown, West Virginia, 26506, United States

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Western Health Sunshine Hospital
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St Albans, Victoria, 3021, Australia

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Wuxi People's Hospital
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Wuxi, Jiangsu, 214023, China

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Yokohama City University Hospital
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Yokohama, Kanagawa, 236-0004, Japan

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Zhongda Hospital Southeast University
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Nanjing, Jiangsu, 210009, China

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Zhongshan Hospital Xiamen University
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Xiamen, Fujian, 361004, China

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Conditions

Explore the condition pages connected to this study.

KIDNEY DISEASE