New hope for aggressive lung cancer: combo therapy enters human trials

NCT ID NCT06362252

Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called ifinatamab deruxtecan (I-DXd) combined with standard immunotherapy (atezolizumab) and sometimes chemotherapy (carboplatin) for people with extensive-stage small cell lung cancer who have not yet been treated. The goal is to see if the combination is safe and helps control the cancer. About 123 adults will take part. This is an early-phase trial, so the main focus is safety and finding the right dose.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTENSIVE-STAGE SMALL CELL LUNG CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Advent Health Orlando
RECRUITING

Orlando, Florida, 32804, United States
Astera Cancer Care
RECRUITING

East Brunswick, New Jersey, 08816, United States
CHU Nantes - Hôpital Guillaume et René Laënnec
RECRUITING

Saint-Herblain, 44805, France
Centre Léon Bérard
RECRUITING

Lyon, 69008, France
Chu Rennes - Hopital Pontchaillou
RECRUITING

Rennes, 35000, France
Columbia University Hervert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States
Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03766, United States
David Geffen School of Medicine
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
Fujita Health University Hospital
RECRUITING

Toyoake-shi, 470-1192, Japan
Henry Ford Hospital
ACTIVE_NOT_RECRUITING

Detroit, Michigan, 48202, United States
Hoag Memorial Hospital Presbyterian
RECRUITING

Newport Beach, California, 92663, United States
Hopital Albert Calmette - Chu Lille
RECRUITING

Lille, 59037, France
Hopital Tenon
RECRUITING

Paris, 75020, France
Hospital Alvaro Cunqueiro
RECRUITING

Vigo, 36312, Spain
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, 29010, Spain
Hospital Universitari Vall D'Hebron
RECRUITING

Barcelona, 8035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hôpital Foch
RECRUITING

Suresnes, 92151, France
Hôpital de la Timone
RECRUITING

Marseille, 13005, France
ICO l'Hospitalet - Hospital Duran i Reynals
RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Ico Girona - Hospital Universitari de Girona Dr Josep Trueta
RECRUITING

Girona, 17007, Spain
Institut Curie - Site de Paris
RECRUITING

Paris, 75005, France
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94805, France
John Theurer Cancer Center At Hackensack Umc
RECRUITING

Hackensack, New Jersey, 07601, United States
Kansai Medical University Hospital
RECRUITING

Hirakata-shi, 573-1191, Japan
Kindai University Hospital
RECRUITING

Ōsaka-sayama, 589-8511, Japan
Lancaster General Hospital - Ann B Barshinger Cancer Institute
RECRUITING

Lancaster, Pennsylvania, 17601, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic-Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10021, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Montefiore Medical Center
RECRUITING

New York, New York, 10461, United States
NHO Himeji Medical Center
RECRUITING

Himeji-shi, 670-8520, Japan
NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States
National Cancer Center Hospital East
RECRUITING

Kashiwa, 277-8577, Japan
New York University Cancer Center - Laura and Isaac Perlmutter Cancer Center At Nyu Langone
RECRUITING

Mineola, New York, 11501, United States
Next Madrid
RECRUITING

Madrid, 28223, Spain
Next Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Niigata Cancer Center Hospital
RECRUITING

Niigata, 951-8566, Japan
Northwest Cancer Specialists, P.C.-Vancouver
RECRUITING

Vancouver, Washington, 98684, United States
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Regents of the University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Scri Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Shizuoka Cancer Center
RECRUITING

Nagaizumi-cho, 411-8777, Japan
Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc. Saiseikai Kumamoto Hospital
RECRUITING

Kumamoto, 861-4193, Japan
The Cancer Institute Hospital of Jfcr
RECRUITING

Kōtoku, 135-8550, Japan
Thomas Jefferson University Hospital - Central
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tokushima University Hospital
RECRUITING

Tokushima, 770-8503, Japan
University of Alabama -Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of Pennsylvania, Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.