New drug ICP-332 aims to soothe stubborn hives when antihistamines fail

NCT ID NCT07378527

Recruiting now Disease control Sponsor: Beijing InnoCare Pharma Tech Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental pill called ICP-332 in 344 adults with moderate to severe chronic spontaneous urticaria (hives) that antihistamines can't control. Participants will take the drug or a placebo for 12 or 24 weeks. The main goal is to see if the drug reduces itching and hives better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ICP-332 tablets
What this could lead to: If successful, this could provide a new oral treatment option for people with chronic hives that don't respond well to standard antihistamines.
What could go wrong: This is an early-to-mid stage trial (Phase 2/3) with 344 participants. The drug may not prove more effective than placebo, and side effects are still being studied.

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Conditions

The condition(s) this trial relates to.

chronic idiopathic urticaria Chronic Urticaria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC SPONTANEOUS URTICARIA (CSU)

Contacts and locations

Locations

Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China
Affiliated Hospital of Jiangsu University
NOT_YET_RECRUITING

Zhenjiang, Jiangsu, 210031, China
Beijing Tongren Hospital, Capital Medical University
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100730, China
Bengbu Medical University First Affiliated Hospital
NOT_YET_RECRUITING

Bengbu, Anhui, 233004, China
Chengdu Second People's Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, 610017, China
Chongqing Traditional Chinese Medicine Hospital
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, 400021, China
Dermatology Hospital of Southern Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510091, China
First Affiliated Hospital of Fujian Medical University
NOT_YET_RECRUITING

Fuzhou, Fujian, 350005, China
First Hospital of Shanxi Medical University
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030001, China
Hangzhou Third People's Hospital
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310009, China
Henan Provincial People's Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, 450003, China
Jinan Central Hospital
NOT_YET_RECRUITING

Jinan, Shandong, 250013, China
Jingzhou Central Hospital
NOT_YET_RECRUITING

Jingzhou, Hubei, 434020, China
Peking University People's Hospital
RECRUITING

Beijing, Beijing Municipality, 100044, China
Shandong Provincial Hospital for Skin Disease, Shandong First Medical University
NOT_YET_RECRUITING

Jinan, Shandong, 250022, China
Shanghai Skin Disease Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200443, China
Shenyang Hospital of Integrated Traditional Chinese and Western Medicine （Shenyang Seventh People's Hospital）
NOT_YET_RECRUITING

Shenyang, Liaoning, 110001, China
Shiyan Taihe Hospital
NOT_YET_RECRUITING

Shiyan, Hubei, 442000, China
Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, 610072, China
Suzhou Municipal Hospital
NOT_YET_RECRUITING

Suzhou, Jiangsu, 215002, China
The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, 400016, China
The First Affiliated Hospital of Kunming Medical University
NOT_YET_RECRUITING

Kunming, Yunnan, 650032, China
The First Affiliated Hospital of Xi'an Jiaotong University
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710061, China
The First Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130021, China
The Second Affiliated Hospital of Henan University of Science and Technology
NOT_YET_RECRUITING

Luoyang, Henan, China
The Second Affiliated Hospital of Wannan Medical College
NOT_YET_RECRUITING

Wuhu, Anhui, 241000, China
The Second Hospital of Hebei Medical University
NOT_YET_RECRUITING

Shijiazhuang, Hebei, 050000, China
Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300131, China
Wuxi No. 2 People's Hospital
NOT_YET_RECRUITING

Wuxi, Jiangsu, 214001, China
Xiangya hospital central south university
NOT_YET_RECRUITING

Changsha, Hunan, 410008, China

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