New hope for older myeloma patients: drug combo shows promise

NCT ID NCT05527340

Ongoing Disease control Sponsor: PETHEMA Foundation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing two drug combinations—iberdomide plus dexamethasone, with or without daratumumab—in 140 newly diagnosed multiple myeloma patients aged 65 or older who are not eligible for a stem cell transplant. The goal is to see how well these treatments control the cancer and how safe they are, especially in frail patients. Participants will receive treatment until the disease worsens or side effects become unacceptable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: iberdomide, dexamethasone, and daratumumab
What this could lead to: If successful, this could offer a new treatment option for older or frail patients with newly diagnosed multiple myeloma who cannot have a stem cell transplant.
What could go wrong: This is a phase 2 trial with only 140 participants, not randomized, so results may not be definitive. The drugs can cause side effects like low blood counts, infections, and fatigue.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Clínica Universidad de Navarra

Pamplona, Spain
Hospital General Universitario Gregorio Marañón

Madrid, Spain
Hospital Son Llatzer

Palma de Mallorca, Spain
Hospital Universitario 12 de Octubre

Madrid, Spain
Hospital Universitario Marqués de Valdecilla

Santander, Spain
Hospital Universitario Virgen del Rocío

Seville, Spain
Hospital Universitario de Canarias

San Cristóbal de La Laguna, Spain
Hospital Universitario de Salamanca

Salamanca, Spain
Hospital Universitario y Politécnico La Fe de Valencia

Valencia, Spain

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