New drug combo aims to boost lymphoma treatment

NCT ID NCT04884035

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests whether adding either iberdomide or CC-99282 to standard chemotherapy (R-CHOP) can safely treat people with untreated aggressive B-cell lymphoma. About 224 adults will take part. The main goals are to find the best dose and check for side effects, while also looking at how well the tumors respond.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

aggressive B-cell non-Hodgkin lymphoma B-cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

Locations

  • AIDPORT Sp. z o.o.

    RECRUITING

    Skórzewo, Greater Poland Voivodeship, 60-185, Poland

    Contact Phone: •••-•••-••••

  • Atrium Health Wake Forest Baptist

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

    Contact Phone: •••-•••-••••

  • Attikon University General Hospital

    RECRUITING

    Athens, 12464, Greece

    Contact Phone: •••-•••-••••

  • Cancer Center Of Kansas-Wichita

    RECRUITING

    Wichita, Kansas, 67214, United States

    Contact Phone: •••-•••-••••

  • China Medical University Hospital

    RECRUITING

    Taichung, 40447, Taiwan

    Contact Phone: •••-•••-••••

  • City Of Hope National Medical Center

    RECRUITING

    Duarte, California, 91010, United States

    Contact Phone: •••-•••-••••

  • Evangelismos General Hospital of Athens

    RECRUITING

    Athens, 10676, Greece

    Contact Phone: •••-•••-••••

  • General Hospital of Athens "Laiko"

    RECRUITING

    Athens, 11 527, Greece

    Contact Phone: •••-•••-••••

  • Georgios Papanikolaou General Hospital of Thessaloniki

    RECRUITING

    Thessaloniki, 57010, Greece

    Contact

  • H. Virgen de la Victoria

    RECRUITING

    Málaga, 29010, Spain

    Contact Phone: •••-•••-••••

  • HealthPartners Cancer Research Center

    RECRUITING

    Saint Louis Park, Minnesota, 55426, United States

    Contact

  • Hospital Universitari Germans Trias i Pujol ICO Badalona

    RECRUITING

    Barcelona, 08916, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca

    RECRUITING

    Salamanca, 37007, Spain

    Contact Phone: •••-•••-••••

  • Intermountain Cancer Center - St George

    RECRUITING

    St. George, Utah, 84790, United States

    Contact

  • Intermountain Medical Oncology

    RECRUITING

    Murray, Utah, 84107, United States

    Contact

  • Levine Cancer Institute

    RECRUITING

    Charlotte, North Carolina, 28204, United States

    Contact

  • Local Institution - 0706

    WITHDRAWN

    Poznan, 60-185, Poland

  • Local Institution - 204

    WITHDRAWN

    Madrid, 28028, Spain

  • Local Institution - 300

    COMPLETED

    Seoul, 06351, South Korea

  • Local Institution - 301

    COMPLETED

    Seoul, 3080, South Korea

  • Local Institution - 302

    COMPLETED

    Seoul, 138-736, South Korea

  • Local Institution - 501

    COMPLETED

    Adelaide, South Australia, 5000, Australia

  • Local Institution - 502

    WITHDRAWN

    Waratah, NSW, Australia

  • Local Institution - 503

    COMPLETED

    Perth, WA 6000, Australia

  • Local Institution - 602

    RECRUITING

    Warsaw, 02-781, Poland

    Contact

  • Local Institution - 604

    COMPLETED

    Wroclaw, 50-367, Poland

  • Local Institution - 703

    WITHDRAWN

    Pátrai, 26500, Greece

  • Local Institution - UNK0706

    WITHDRAWN

    Poznan, 60-185, Poland

  • MCM Krakow - PRATIA - PPDS

    RECRUITING

    Krakow, 30-727, Poland

    Contact Phone: •••-•••-••••

  • MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77003, United States

    Contact Phone: •••-•••-••••

  • Mayo Clinic - Arizona

    RECRUITING

    Scottsdale, Arizona, 85259, United States

    Contact Phone: •••-•••-••••

  • Mayo Clinic - Jacksonville

    WITHDRAWN

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic - Rochester

    RECRUITING

    Rochester, Minnesota, 55905-0001, United States

    Contact Phone: •••-•••-••••

  • Mayo Clinic Jacksonville - PPDS

    RECRUITING

    Jacksonville, Florida, 32224, United States

    Contact Phone: •••-•••-••••

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 100229, Taiwan

    Contact Phone: •••-•••-••••

  • Northwest Georgia Oncology Centers PC

    RECRUITING

    Marietta, Georgia, 30060, United States

    Contact Phone: •••-•••-••••

  • Roswell Park Cancer Institute

    WITHDRAWN

    Buffalo, New York, 14263, United States

  • SP ZOZ Szpital Uniwersytecki w Krakowie

    RECRUITING

    Słomniki, 32-090, Poland

    Contact Phone: •••-•••-••••

  • Taichung Veterans General Hospital

    RECRUITING

    Taichung, 407, Taiwan

    Contact Phone: •••-•••-••••

  • University Hospital (University Of Alabama Hospital)

    RECRUITING

    Birmingham, Alabama, 35233, United States

    Contact

  • University Of Kansas Medical Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

    Contact Phone: •••-•••-••••

  • University of Nebraska - Fred and Pamela Buffet Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

    Contact Phone: •••-•••-••••

  • Uniwersyteckie Centrum Kliniczne

    RECRUITING

    Gdansk, 80-952, Poland

    Contact Phone: •••-•••-••••