Pacemaker's 'Smart Pacing' may zap away heart danger without shocks

NCT ID NCT04496518

Ongoing Disease control Sponsor: Medtronic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is checking how well a special pacemaker feature called iATP works in everyday medical practice. The iATP automatically sends tiny, painless electrical pulses to stop a fast, dangerous heart rhythm called ventricular tachycardia. Researchers are tracking 2,200 people who already have or will get a compatible pacemaker to see if iATP can safely reduce the need for painful defibrillator shocks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intrinsic Antitachycardia Pacing (iATP) therapy via an implanted device
What this could lead to: If successful, this could confirm that iATP is a reliable way to stop dangerous heart rhythms without painful shocks, improving quality of life for people with pacemakers.
What could go wrong: This is a post-approval study confirming real-world safety, not a new breakthrough. The therapy may not work for all types of fast heart rhythms, and some patients may still experience fainting or shocks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENTRICULAR TACHYCARDIA

Contacts and locations

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Locations

Associates in Cardiology PA

Silver Spring, Maryland, 20910-1265, United States
Athens Medical Center

Marousi, 15125, Greece
Aurora Cardiovascular Services

Milwaukee, Wisconsin, 53215-3678, United States
Azienda Ospedaliera ospedale Niguarada ca Granda

Milan, 20162, Italy
Azienda Sanitaria Provinciale di Cosenza"Ospedale di Castrovillari"

Castrovillari, 87012, Italy
Azienda ospedaleria Santa Maria dellaMisericordia di Udine

Udine, 33100, Italy
Baptist Health

Jacksonville, Florida, 32207-8208, United States
Blackpool, Fylde and Wyre Hospitals NHSFoundation Trust - Blackpool Victoria Hospital

Blackpool, FY3 8NR, United Kingdom
Brigham and Women's Hospital (Boston MA)

Boston, Massachusetts, 02115-6110, United States
CHRU La Rochelle

La Rochelle, 17019, France
CHU Clermont-Ferrand - Gabriel-Montpied

Clermont-Ferrand, 63003, France
CHU de Brest

Brest, 29609, France
CHU de Caen - Hôpital Côte de Nacre - Centre Esquirol

Caen, 14033, France
CHU de Dijon - Hospital Le Bocage

Dijon, 21079, France
Capio - Clinique du Tonkin

Villeurbanne, 69100, France
Cardiology Associates Medical Group

Ventura, California, 93003, United States
Cardiopark Zurich

Zurich, 8027, Switzerland
Cardiovascular Consultants Medical Group (Van Nuys CA)

Van Nuys, California, 91405, United States
Cardiovascular Institute of Northwest Florida

Panama City, Florida, 32405, United States
Central Manchester University Hospitals NHS - mancester Royal Infirmary

Manchester, M13 9WL, United Kingdom
Centre Hospitalier Universitaire Saint Étienne

Saint-Priest-en-Jarez, 42270, France
Centre hospitalier de la région d'Annecy

Pringy, 74374, France
Centro Hospitalar Universitário de SãoJoão Alameda

Porto, 4200-319, Portugal
Chula Vista Cardiac Center

Chula Vista, California, 91910, United States
Clinique Rhône Durance

Avignon, 84082, France
Colorado Heart and Vascular, PC

Lakewood, Colorado, 80228, United States
Colorado Springs Cardiology

Colorado Springs, Colorado, 80907, United States
Complejo Hospitalario Universitario de Santiago de Compostela

Santiago, 15706, Spain
Complejo Universitario de Salamanca

Salamanca, 37007, Spain
Consultants in Cardiology (Fort Worth TX)

Fort Worth, Texas, 76104, United States
Deaconess Specialty Physicians

Evansville, Indiana, 47710, United States
Denver Heart

Denver, Colorado, 80220, United States
Générale de Santé - Hôpital Privé Saint Martin

Caen, 14000, France
Hartford Hospital

Hartford, Connecticut, 06102, United States
Heart & Vascular Institute of Florida

Safety Harbor, Florida, 34695-6604, United States
Heart Center of North Texas

Fort Worth, Texas, 761014, United States
Heart Rhythm Consultants P.A. (Sarasota Memorial Research)

Sarasota, Florida, 34233, United States
Heart Rhythm Solutions

Hollywood, Florida, 33021-3552, United States
Hospital Clínico Universitario de Valladolid

Valladolid, 47006, Spain
Hospital Distrital de Santarém

Santarém, 2000-177, Portugal
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Clínico San Cecilio

Granda, 18016, Spain
Hospital Universitario Nuestra Señora de Candelaria

Santa Cruz de Tenerife, 38010, Spain
Hospital Universitario Virgen de las Nieves

Granda, 18014, Spain
Hospital Universitario da coruna

A Coruña, 15006, Spain
Hospital da Senhora da Oliveira -Guimarães

Guimarães, 4835-044, Portugal
Hospital de Santa Maria-Centro HospitalarLisboa Norte, EPE

Lisbon, 1649-035, Portugal
Hudson Valley Heart Center

Poughkeepsie, New York, 12601-3923, United States
Huntington Hospital

Huntington, New York, 11743, United States
Hygeia Hospital

Athens, 15123, Greece
Hôpitaux Universitaires de Genève

Geneva, 1205, Switzerland
Imperial College Healthcare NHS Trust Hammersmith Hospital

London, W12 0HS, United Kingdom
Iowa Heart Center (West Des Moines IA)

Des Moines, Iowa, 50266, United States
Lenox Hill Hospital

New York, New York, 10075, United States
Liverpool Heart and Chest Hospital NHS Foundation Trust

Liverpool, L14 3PE, United Kingdom
Long Island Jewish Medical Center

New Hyde Park, New York, 11040, United States
Mayo Clinic (Rochester MN)

Rochester, Minnesota, 55902-1906, United States
Michigan Heart

Ypsilanti, Michigan, 48197-8633, United States
Missouri Cardiovascular Specialists

Columbia, Missouri, 65201-8023, United States
Monmouth Cardiology Associates

Ocean City, New Jersey, 07712-4764, United States
Nebraska Medicine

Omaha, Nebraska, 68105, United States
New York-Presbyterian Hospital/Weill Cornell Medical Center

New York, New York, 10021, United States
NewYork-Presbyterian/Columbia University Irving Medical Center

New York, New York, 10032, United States
North Shore University Hospital

Manhasset, New York, 11030, United States
Northern Westchester Hospital

Mount Kisco, New York, 10549, United States
Norton Heart and Vascular Institute

Louisville, Kentucky, 40205, United States
Nouvelles Cliniques Nantaises

Nantes, 44277, France
Národný ústav srdcových a cievnych chorôb, a.s. (NUSCH, a.s.)

Bratislava, Slovakia
Ospedale "Vito Fazzi" Lecce

Lecce, 73100, Italy
Policlinico Sant' Orsola - Malpighi

Bologna, 40138, Italy
Presbyterian Heart Group

Albuquerque, New Mexico, 87106-4921, United States
Presidio Ospedaliero Centrale - SS.Annunziata

Taranto, 74024, Italy
Saint Lukes Health System

Kansas City, Missouri, 64111-5934, United States
Saint Thomas Research Institute

Nashville, Tennessee, 37205-2018, United States
Saint Vincent Heart Clinic Arkansas

Little Rock, Arkansas, 72205-6202, United States
Sheffield Vascular Institute, Sheffield TeachingHospitals NHS - Northern Genera

Sheffield, S5 7AU, United Kingdom
South Shore University Hospital

Bay Shore, New York, 11706, United States
Southwest EP

Chandler, Arizona, 85226, United States
Sparrow Clinical Research Institute

Lansing, Michigan, 48912, United States
St Luke's University Health Network

Bethlehem, Pennsylvania, 18015-1000, United States
Staten Island University Hospital

Staten Island, New York, 10305-3436, United States
Summa Center for Clinical Trials-Northeast Ohio Cardiovascular Specialists

Akron, Ohio, 44304-1473, United States
Texas Cardiac Arrhythmia Research Foundation

Austin, Texas, 78705-1852, United States
The Christ Hospital Health Network

Cincinati, Ohio, 45219, United States
The James Cook University Hospital - SouthTees Hospitals NHS

Middlesbrough, TS4 3BW, United Kingdom
The University of Kansas Medical Center

Kansas City, Kansas, 66160-8500, United States
Tidal Health Peninsula Regional

Salisbury, Maryland, 21801, United States
University Hospital (Columbia MO)

Columbia, Missouri, 65201, United States
University Hospitals of Birmingham NHS Foundation Trust - Queen Elizabeth Hospital

Birmingham, B15 2GW, United Kingdom
WakeMed Health & Hospitals

Raleigh, North Carolina, 27610, United States
Washington University School of Medicine

St Louis, Missouri, 63110-1010, United States
Yale New Haven Hospital

New Haven, Connecticut, 06510, United States

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