New shot could tame lupus kidney flares

NCT ID NCT05126277

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding ianalumab (a biologic injection) to standard therapy helps control active lupus nephritis, a serious kidney complication of lupus. About 452 adults with active lupus nephritis are receiving either ianalumab every 4 or 12 weeks or a placebo, alongside their usual care. The main goal is to see if more people achieve a stable complete kidney response by 72 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ianalumab (a biologic drug given as a shot under the skin)

What this could lead to

If it works, this could provide a new treatment option for people with lupus nephritis, helping to control kidney inflammation and reduce the need for strong immune-suppressing drugs.

What could go wrong

This is still a clinical trial, so it is not yet proven to work. Even if successful, the drug may only help some patients and could have side effects like infections or allergic reactions.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

lupus nephritis nephritis systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUPUS NEPHRITIS

Contacts and locations

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Locations

Accurate Clinical Research

Lake Charles, Louisiana, 70601, United States
Advanced Medical Research

La Palma, California, 90623, United States
Circuit Clinical

Orchard Park, New York, 14127, United States
Emory University School of Medicine

Atlanta, Georgia, 30303, United States
Fides Clinical Research

Atlanta, Georgia, 30342, United States
Hospital for Special Surgery

New York, New York, 10021, United States
James J Peters VA Medical Center

The Bronx, New York, 10468, United States
Kaiser Permanente

San Diego, California, 92111, United States
Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States
NY Nephrology

Clifton Park, New York, 12065, United States
Northern Assoc of Northern VA

Fairfax, Virginia, 22033, United States
Northwell Health

New York, New York, 10028, United States
Novartis Investigative Site

CABA, Buenos Aires, C1056ABI, Argentina
Novartis Investigative Site

La Plata, Buenos Aires, B1900AWT, Argentina
Novartis Investigative Site

Caba, C1015ABO, Argentina
Novartis Investigative Site

CABA, C1426ABP, Argentina
Novartis Investigative Site

San Miguel de Tucumán, 4000, Argentina
Novartis Investigative Site

Vitória, Espírito Santo, 29055 450, Brazil
Novartis Investigative Site

Salvador, Estado de Bahia, 40150 150, Brazil
Novartis Investigative Site

Belo Horizonte, Minas Gerais, 30150-221, Brazil
Novartis Investigative Site

Juiz de Fora, Minas Gerais, 36010 570, Brazil
Novartis Investigative Site

Recife, Pernambuco, 50740-900, Brazil
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90035-003, Brazil
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90035-074, Brazil
Novartis Investigative Site

Santo André, São Paulo, 09090-790, Brazil
Novartis Investigative Site

Salvador, 40323-010, Brazil
Novartis Investigative Site

Calgary, Alberta, T2N 4Z6, Canada
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Vancouver, British Columbia, V5Z 1L7, Canada
Novartis Investigative Site

Winnipeg, Manitoba, R3A 1R9, Canada
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Etobicoke, Ontario, M9W 6V1, Canada
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London, Ontario, N6A 5W9, Canada
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Toronto, Ontario, M5T 2S8, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Sherbrooke, Quebec, J1G 2E8, Canada
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Santiago, RM, 7500922, Chile
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Temuco, 4781151, Chile
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Guangzhou, Guangdong, 510000, China
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Guangzhou, Guangdong, 510080, China
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Guangzhou, Guangdong, 510120, China
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Shantou, Guangdong, 515000, China
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Shenzhen, Guangdong, 518037, China
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Liuzhou, Guangxi, 545005, China
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Haikou, Hainan, 570311, China
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Wuhan, Hubei, 430022, China
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Wuhan, Hubei, 430060, China
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Changsha, Hunan, 410008, China
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Nanjing, Jiangsu, 210029, China
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Nanchang, Jiangxi, 330006, China
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Changchun, Jilin, 130041, China
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Shenyang, Liaoning, 110004, China
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Binzhou, Shandong, 256603, China
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Linyi, Shandong, 276000, China
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Xian, Shanxi, 710004, China
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Chengdu, Sichuan, 610041, China
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Ningbo, Zhejiang, 315016, China
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Beijing, 100034, China
Novartis Investigative Site

Chongqing, 400038, China
Novartis Investigative Site

Guangzhou, 510080, China
Novartis Investigative Site

Guangzhou, 510280, China
Novartis Investigative Site

Shanghai, 200040, China
Novartis Investigative Site

Shanghai, 200080, China
Novartis Investigative Site

Shanghai, 200127, China
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Medellín, Antioquia, 050001, Colombia
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Barranquilla, Atlántico, 080020, Colombia
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Bogota, Cundinamarca, 110111, Colombia
Novartis Investigative Site

Olomouc, 779 00, Czechia
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Prague, 128 00, Czechia
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Tallinn, 10117, Estonia
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Tallinn, 10138, Estonia
Novartis Investigative Site

Besançon, 25030, France
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Bordeaux, 33076, France
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Grenoble, 38043, France
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Lyon, 69003, France
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Marseille, 13005, France
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Poitiers, 86021, France
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Toulouse, 31054, France
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Vandœuvre-lès-Nancy, 54511, France
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Aachen, 52074, Germany
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Bochum, 44791, Germany
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Guatemala City, 01010, Guatemala
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Guatemala City, 01011, Guatemala
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Quetzaltenango, 9001, Guatemala
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Kwun Tong, Kowloon, 999077, Hong Kong
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Tuenmen, 999077, Hong Kong
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Debrecen, Hajdu Bihar Megye, 4032, Hungary
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Budapest, H-1032, Hungary
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Budapest, H-1097, Hungary
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Kaposvár, 7400, Hungary
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Bangalore, Karnataka, 560 079, India
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Secunderabad, Telangana, 500003, India
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Lucknow, Uttar Pradesh, 226014, India
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Chandigarh, 160 012, India
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Pavia, PV, 27100, Italy
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Udine, UD, 33100, Italy
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Kaunas, LTU, LT 50161, Lithuania
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Vilnius, LT-08406, Lithuania
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Kuala Lumpur, Kuala Lumpur, 50586, Malaysia
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Sibu, Sarawak, 96000, Malaysia
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Kuala Terengganu, Terengganu, 20400, Malaysia
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León, Guanajuato, 37160, Mexico
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Monterrey, Nuevo León, 64440, Mexico
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Oaxaca City, 68020, Mexico
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Querétaro, 76070, Mexico
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Cluj-Napoca, Cluj, 400006, Romania
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Oradea, Jud Bihor, 410619, Romania
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Timișoara, Timiș County, 300723, Romania
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Bucharest, 011172, Romania
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Bucharest, 022328, Romania
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Singapore, 169608, Singapore
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Singapore, S308433, Singapore
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Bundang Gu, Gyeonggi-do, 13620, South Korea
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Suwon, Gyeonggi-do, 16499, South Korea
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Busan, 49201, South Korea
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Gwangju, 61469, South Korea
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Seoul, 03722, South Korea
Novartis Investigative Site

Seoul, 04763, South Korea
Novartis Investigative Site

Seoul, 05505, South Korea
Novartis Investigative Site

Seoul, 06591, South Korea
Novartis Investigative Site

Santiago Compostela, A Coruna, 15706, Spain
Novartis Investigative Site

Barcelona, Catalonia, 08003, Spain
Novartis Investigative Site

Pamplona, Navarre, 31008, Spain
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Vigo, Pontevedra, 36214, Spain
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San Cristóbal de La Laguna, Santa Cruz De Tenerife, 38320, Spain
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Valencia, Valencia, 46017, Spain
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Barcelona, 08035, Spain
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Madrid, 28040, Spain
Novartis Investigative Site

Madrid, 28041, Spain
Novartis Investigative Site

Madrid, 280796, Spain
Novartis Investigative Site

Kaohsiung City, 83301, Taiwan
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Taichung, 40447, Taiwan
Novartis Investigative Site

Taichung, 407219, Taiwan
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Taipei, 11217, Taiwan
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Songkhla, Hat Yai, 90110, Thailand
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Bangkok, 10330, Thailand
Novartis Investigative Site

Bangkok, 10400, Thailand
Novartis Investigative Site

Bangkok, 10700, Thailand
Novartis Investigative Site

Chiang Mai, 50200, Thailand
Novartis Investigative Site

Bradford, West Yorkshire, BD9 6RJ, United Kingdom
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London, SE1 9RT, United Kingdom
Novartis Investigative Site

Hanoi, 100000, Vietnam
Novartis Investigative Site

Ho Chi Minh City, 700000, Vietnam
Parris and Associates Rheumatology

Lawrenceville, Georgia, 30044, United States
Precision Comprehensive Research

Colleyville, Texas, 76034, United States
School Of Medicine

Sacramento, California, 95817, United States
UMC New Orleans

New Orleans, Louisiana, 70112, United States
Uni Wisconsin School Med Pub Health

Madison, Wisconsin, 53792, United States
Uni of Texas Health Science Center

San Antonio, Texas, 78229, United States
Univ of Nevada School of Med

Las Vegas, Nevada, 89102, United States
Univ of Pennsylvania Medical Center

Philadelphia, Pennsylvania, 19104, United States
University Of Alabama

Birmingham, Alabama, 35294, United States
University Of Cincinnati

Cincinnati, Ohio, 45267, United States
University Of Miami

Miami, Florida, 33136, United States
University of California Irvine

Orange, California, 92868, United States
University of California San Diego

San Diego, California, 92037, United States
Univof Texas Southwestern Med Cntr

Dallas, Texas, 75235, United States
Wayne State University

Detroit, Michigan, 48201, United States