New drug trial aims to tame hardening skin and lung damage in scleroderma

NCT ID NCT06470048

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether the drug ianalumab can help people with diffuse cutaneous systemic sclerosis, a condition that causes skin thickening and can damage internal organs like the lungs. About 200 adults will receive either ianalumab or a placebo as a shot under the skin. Researchers will check if the drug improves skin and lung function after one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ianalumab (a drug given as a shot under the skin)

What this could lead to

If it works, this could point toward a new treatment option to control skin and lung complications in people with diffuse cutaneous systemic sclerosis.

What could go wrong

This is an early Phase 2 trial with only 200 participants, so results may not confirm benefit. The drug may cause side effects or fail to outperform placebo.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

diffuse cutaneous systemic sclerosis diffuse scleroderma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS

Contacts and locations

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Arizona Arthritis and Rheumatology Research PLLC
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Mesa, Arizona, 85202, United States

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Arthritis and Rheumatology Ins
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Allen, Texas, 75013, United States

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Clinical Res Of W Florida
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Clearwater, Florida, 33765, United States

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Clinical Research Inst of MI
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Saint Clair Shores, Michigan, 48081, United States

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GNP Research
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Cooper City, Florida, 33024, United States

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Hoag Hospital
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Newport Beach, California, 92663, United States

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Hospital for Special Surgery
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New York, New York, 10021, United States

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IRIS Research and Development
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Plantation, Florida, 33324, United States

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Novartis Investigative Site
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CABA, Buenos Aires, 1280, Argentina
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CABA, Buenos Aires, C1221ADC, Argentina
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Caba, C1015ABO, Argentina
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Caba, C1427CCL, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Graz, 8036, Austria
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Leuven, 3000, Belgium
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Salvador, Estado de Bahia, 40150 150, Brazil
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Curitiba, Paraná, 80030-110, Brazil
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Porto Alegre, Rio Grande do Sul, 90035-074, Brazil
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Sao Jose Rio Preto, São Paulo, 15090 000, Brazil
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São Paulo, São Paulo, 04038-002, Brazil
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São Paulo, São Paulo, 05403-000, Brazil
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Nanning, Guangxi, 530021, China
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Zhengzhou, Henan, 450003, China
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Changchun, Jilin, 130021, China
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Chengdu, Sichuan, 610041, China
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Ningbo, Zhejiang, 315016, China
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Beijing, 100191, China
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Beijing, 100730, China
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Tianjin, 300052, China
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Medellín, Antioquia, 050001, Colombia
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Bogota, Cundinamarca, 110111, Colombia
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Bogota, Cundinamarca, 110221, Colombia
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Cali, Valle del Cauca Department, 760012, Colombia
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Bogotá, 110231, Colombia
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Medellín, 050034, Colombia
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Dijon, 21000, France
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Le Mans, 72000, France
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Lille, 59037, France
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Montpellier, 34295, France
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Paris, 75014, France
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Rennes, 35033, France
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Strasbourg, 67000, France
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Toulouse, 31054, France
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Würzburg, Bavaria, 97080, Germany
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Jena, Thuringia, 07740, Germany
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Berlin, 13353, Germany
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Alexandroupoli, 681 00, Greece
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Athens, 115 21, Greece
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Athens, 115 27, Greece
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Pécs, Baranya, 7623, Hungary
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Debrecen, Hajdu Bihar Megye, 4032, Hungary
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Budapest, H-1083, Hungary
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Kochi, Kerala, 682018, India
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Mumbai, Maharashtra, 400013, India
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Mumbai, Maharashtra, 400078, India
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New Delhi, National Capital Territory of Delhi, 110060, India
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Jaipur, Rajasthan, 302004, India
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New Delhi, 110029, India
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Ancona, AN, 60126, Italy
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Milan, MI, 20100, Italy
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Rozzano, MI, 20089, Italy
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Modena, MO, 41124, Italy
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Palermo, PA, 90127, Italy
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Pavia, PV, 27100, Italy
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Roma, RM, 00168, Italy
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Verona, VR, 37134, Italy
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Nagoya, Aichi-ken, 4578510, Japan
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Toyoake, Aichi-ken, 4701192, Japan
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Kitakyushu, Fukuoka, 8078556, Japan
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Maebashi, Gunma, 3718511, Japan
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Sapporo, Hokkaido, 060-8648, Japan
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Sapporo, Hokkaido, 0608543, Japan
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Yokohama, Kanagawa, 236-0004, Japan
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Suita, Osaka, 565-0871, Japan
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Iruma-gun, Saitama, 3500495, Japan
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Bunkyo-ku, Tokyo, 113-8603, Japan
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Chuo Ku, Tokyo, 104-8560, Japan
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Shinjuku Ku, Tokyo, 1628666, Japan
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Shinjuku-ku, Tokyo, 1608582, Japan
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Fukuoka, 8128582, Japan
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Hiroshima, 7348551, Japan
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Ishikawa, 9208641, Japan
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Kyoto, 6068507, Japan
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Toyama, 9300194, Japan
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Cheras, Kuala Lumpur, 56000, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Guadalajara, Jalisco, 44650, Mexico
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Mexico City, Mexico City, 06700, Mexico
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Mexico City, Mexico City, 11850, Mexico
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Monterrey, Nuevo León, 64460, Mexico
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Chihuahua City, 31000, Mexico
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Bydgoszcz, 85-168, Poland
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Warsaw, 00-874, Poland
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Coimbra, 3004-561, Portugal
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Lisbon, 1649-035, Portugal
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Vila Nova de Gaia, 4434 502, Portugal
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Busan, 49241, South Korea
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Seoul, 03080, South Korea
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Seoul, 04763, South Korea
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Seoul, 06273, South Korea
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Málaga, Andalusia, 29009, Spain
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Valencia, Valencia, 46017, Spain
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Barcelona, 08041, Spain
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Kaohsiung City, 83301, Taiwan
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Taichung, 40447, Taiwan
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Taoyuan, 33305, Taiwan
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Khon Kaen, THA, 40002, Thailand
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Bangkok, 10400, Thailand
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Istanbul, Fatih, 34093, Turkey (Türkiye)
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Ankara, Sihhiye-Altindag, 06230, Turkey (Türkiye)
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Ankara, Yenimahalle, 06500, Turkey (Türkiye)
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Basingstoke, Hampshire, RG24 9NA, United Kingdom
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Bristol, BS10 5NB, United Kingdom
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London, NW3 2QG, United Kingdom
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Ho Chi Minh City, VNM, 700000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
Novel Research LLC
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Bellaire, Texas, 77401, United States

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Prolato Clinical Research Center
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Houston, Texas, 77054, United States

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New Orleans, Louisiana, 70112, United States

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Ann Arbor, Michigan, 48109, United States

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Jackson, Tennessee, 38305, United States

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