Can pressurized oxygen lift the fog of Post-Stroke depression?

NCT ID NCT07423273

Recruiting now Symptom relief Sponsor: Assaf-Harofeh Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can reduce depression in people who have had a stroke. Researchers will compare the treatment to a sham (fake) procedure in 142 adults aged 50-85 who have been depressed for at least 3 months despite medication. The goal is to see if this non-drug approach can improve mood and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyperbaric oxygen therapy
What this could lead to: If it works, this could offer a new way to treat depression that lingers after a stroke, without adding more medication.
What could go wrong: This is a small, early-stage trial with no phase designation. The treatment requires 60 daily sessions, which may be hard to complete, and results may not apply to all stroke survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-STROKE DEPRESSION

Contacts and locations

Locations

The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh)
RECRUITING

Zrifin, 70300, Israel

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