Can pressurized oxygen lift the fog of Post-Stroke depression?
NCT ID NCT07423273
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can reduce depression in people who have had a stroke. Researchers will compare the treatment to a sham (fake) procedure in 142 adults aged 50-85 who have been depressed for at least 3 months despite medication. The goal is to see if this non-drug approach can improve mood and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hyperbaric oxygen therapy
What this could lead to
If it works, this could offer a new way to treat depression that lingers after a stroke, without adding more medication.
What could go wrong
This is a small, early-stage trial with no phase designation. The treatment requires 60 daily sessions, which may be hard to complete, and results may not apply to all stroke survivors.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh)
RECRUITINGZrifin, 70300, Israel
Contact Phone: •••-•••-•••• Email: •••••@•••••