Could a Fluoride-Free toothpaste fix Kids' enamel defects?
NCT ID NCT07177053
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares a fluoride-free hydroxyapatite toothpaste to standard fluoride toothpaste for repairing enamel in children aged 6-12 with Molar Incisor Hypomineralization (MIH), a condition causing weak, sensitive teeth. Over 12 months, researchers will measure changes in enamel fluorescence and lesion size using special imaging. The goal is to see if the hydroxyapatite toothpaste can effectively remineralize teeth while addressing parents' concerns about fluoride.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hydroxyapatite toothpaste (KAREX KINDER) and fluoride toothpaste (Colgate Total PROTECTION ACTIVE)
What this could lead to
If it works, this could offer a fluoride-free alternative to help repair enamel and reduce sensitivity in children with Molar Incisor Hypomineralization.
What could go wrong
This is a Phase 2 trial with 160 children, so results are preliminary. The hydroxyapatite toothpaste may not be as effective as fluoride, and the study is open-label, which can introduce bias.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.