Could a Fluoride-Free toothpaste fix Kids' enamel defects?

NCT ID NCT07177053

Not yet recruiting Disease control Sponsor: Dubai Health Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compares a fluoride-free hydroxyapatite toothpaste to standard fluoride toothpaste for repairing enamel in children aged 6-12 with Molar Incisor Hypomineralization (MIH), a condition causing weak, sensitive teeth. Over 12 months, researchers will measure changes in enamel fluorescence and lesion size using special imaging. The goal is to see if the hydroxyapatite toothpaste can effectively remineralize teeth while addressing parents' concerns about fluoride.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hydroxyapatite toothpaste (KAREX KINDER) and fluoride toothpaste (Colgate Total PROTECTION ACTIVE)
What this could lead to: If it works, this could offer a fluoride-free alternative to help repair enamel and reduce sensitivity in children with Molar Incisor Hypomineralization.
What could go wrong: This is a Phase 2 trial with 160 children, so results are preliminary. The hydroxyapatite toothpaste may not be as effective as fluoride, and the study is open-label, which can introduce bias.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MOLAR INCISOR HYPOMINERALISATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Molar Hypomineralization

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MOLAR INCISOR HYPOMINERALISATION

More trials for these conditions

Other studies related to the condition(s) this trial covers.