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Hyaluronic acid gel vs standard paste: which calms infected root canals better?

NCT ID NCT07821866

Symptom relief Sponsor: Future University in Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers compare two medicines placed inside root canals during a two-visit root canal treatment for infected mandibular molars. One medicine is Hyalone, a hyaluronic acid gel, and the other is calcium hydroxide, a standard disinfectant paste. The trial enrolls 24 adults with necrotic pulp and painful apical periodontitis. Participants record their pain for a week after the medicine is placed, and researchers use cone-beam CT scans to check healing around the root tip.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hyalone, a hyaluronic acid-based gel used as an intracanal medicament
What this could lead to
If Hyalone works better, it could offer dentists a new option for easing pain and helping healing during two-visit root canal treatment.
What could go wrong
This is a very early, small study with only 24 people, so results may not hold up in larger groups. Root canal treatment can still leave pain or need more visits regardless of the medicament used.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

24 people

The number who actually took part.

Started

Apr 2026

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Medically free patients with no systemic disease: (American Society of Anesthesiologists / (ASA Class I or II). * Age range is between 20 to 40 years. * Patients have restorable permanent mandibular first molars (mesial root type III and distal canal type III) that were diagnosed necrotic with symptomatic apical periodontitis with small to moderate periapical lesion less that 5 mm according to CBCT-PAI in highest diameter at any axis in CBCT). * Positive patient's acceptance for participating in the study. * Patients able to sign informed consent Exclusion Criteria: * • Medically compromised patients. * Pregnant or lactating females. * Psychologically disturbed patients. * Patients with a history of allergy to any medication used in the study were excluded. Teeth that have: * Periodontally affected with grade 2 or 3 mobility. * Not restorable teeth. * Abnormal anatomy and calcified canals. * Previous root canal treatment.

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Conditions

The condition(s) this trial relates to.

agnosia dental pulp necrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain management

Contacts and locations

Locations

  • Faculty of Oral and Dental Medicine, Future University in Egypt

    Cairo, Egypt

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