New Dual-Action antibody shows promise for tough lymphoma cases

NCT ID NCT05189093

First seen Nov 01, 2025 · Last updated Apr 25, 2026 · Updated 25 times

Summary

This early-phase trial tested a new drug called HX009 in 48 adults with lymphoma that returned or didn't respond to prior treatments. HX009 is a bifunctional antibody designed to block two proteins (CD47 and PD-1) that help cancer hide from the immune system. The goal was to see if the drug could shrink tumors and how safe it was, but since patients may need ongoing therapy, this is considered disease control, not a cure.

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Contacts and locations

Locations

  • Cancer Hospital Chinese Academy of Medical Sciense

    Beijing, Beijing Municipality, China

Conditions

Explore the condition pages connected to this study.