New combo drug aims to cut opioid use after bunion surgery

NCT ID NCT03295721

Completed Symptom relief Sponsor: Heron Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This completed Phase 3 trial tested HTX-011, a combination of bupivacaine and meloxicam, for pain relief after bunionectomy. 412 adults received either HTX-011, a saline placebo, or standard bupivacaine directly into the surgical site. The goal was to see if HTX-011 reduces pain and the need for opioid painkillers in the first 72 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HTX-011 (bupivacaine/meloxicam)
What this could lead to: If it works, this could provide a new option for managing pain after foot surgery while reducing the need for opioid painkillers.
What could go wrong: This is a completed Phase 3 trial, so results are available, but the treatment is only for a specific surgery and may not work for other types of pain. Risks include side effects from the drug combination.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Bunion Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE PAIN

Contacts and locations

Locations

Alliance Research Centers

Laguna Hills, California, 92653, United States
Anaheim Clinical Trials, LLC

Anaheim, California, 92801, United States
Arizona Research Center

Phoenix, Arizona, 85059, United States
Chesapeake Research Group, LLC

Pasadena, Maryland, 21122, United States
EPIC Medical Research, LLC

Murray, Utah, 84123, United States
Endeavor Clinical Trials

San Antonio, Texas, 78229, United States
Futuro Clinical Trials, LLC

McAllen, Texas, 78501, United States
Hermann Drive Surgical Hospital

Houston, Texas, 77004, United States
Jean Brown Research

Salt Lake City, Utah, 84124, United States
Optimal Research , LLC

Austin, Texas, 78705, United States
Orthopaedic Specialists of North America, PLLC

Mesa, Arizona, 85206, United States
Plano Surgical Hospital

Plano, Texas, 75093, United States
Springhill Medical Center

Mobile, Alabama, 36608, United States
Trovare Clinical Research, Inc.

Bakersfield, California, 93301, United States
Westside Surgical Hospital

Houston, Texas, 77027, United States

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