New combo drug aims to cut opioid use after hernia surgery
NCT ID NCT03237481
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a drug called HTX-011, which combines two pain relievers (bupivacaine and meloxicam), to see if it can control pain better than standard treatments after hernia surgery. 418 adults having open inguinal hernia repair received either HTX-011, a standard painkiller, or a placebo. The goal was to measure pain levels and how much opioid pain medicine was needed during the first 72 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HTX-011 (a combination of bupivacaine and meloxicam)
- What this could lead to
- If it works, this could provide a new option for managing pain after surgery with less need for opioids.
- What could go wrong
- This is a completed Phase 3 trial, but results may not apply to all surgeries or patients. Pain relief may not be better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Alliance Research Centers
Laguna Hills, California, 92653, United States
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American Institute of Research
Whittier, California, 90603, United States
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Anaheim Clinical Trials, LLC
Anaheim, California, 92801, United States
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Arizona Research Center
Phoenix, Arizona, 85053, United States
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Cornerstone Research Institute, LLC
Longwood, Florida, 32750, United States
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EPIC Medical Research, LLC
Murray, Utah, 84123, United States
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Eliza Coffee Memorial Hospital
Florence, Alabama, 35630, United States
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Endeavor Clinical Trials, P.A.
San Antonio, Texas, 78229, United States
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HD Research Corp
Riverside, California, 92503, United States
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Hermann Drive Surgical Hospital
Houston, Texas, 77004, United States
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Jean Brown Research
Salt Lake City, Utah, 84124, United States
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Jessa Ziekenhuis
Hasselt, Limburg, 3500, Belgium
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Lotus Clinical Research, LLC
Pasadena, California, 91105, United States
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Midwest Clinical Research
Dayton, Ohio, 45417, United States
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Park Place Surgery Center
Maitland, Florida, 32751, United States
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Plano Surgical Hospital
Plano, Texas, 75093, United States
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Shoals Medical Trials, Inc.
Sheffield, Alabama, 35660, United States
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St. Louis Clinical Trials
St Louis, Missouri, 63141, United States
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Trovare Clinical Research, Inc.
Bakersfield, California, 93301, United States
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University of Miami
Miami, Florida, 33136, United States
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Westside Surgical Hospital
Houston, Texas, 77027, United States
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Yale University School of Medicine
New Haven, Connecticut, 06511, United States
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Ziekenhuis Oost Limburg
Genk, 3600, Belgium
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eStudySite
Las Vegas, Nevada, 89109, United States
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