New drug cocktail aims to slash opioid use after hernia surgery

NCT ID NCT03695367

Completed Symptom relief Sponsor: Heron Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tested a drug called HTX-011 (a mix of bupivacaine and meloxicam) in 63 adults having open inguinal hernia repair. The goal was to see if this painkiller combo, along with other non-opioid medicines, could reduce the need for opioid painkillers after surgery. The study is complete, and researchers measured how many people needed no opioids at all.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HTX-011 (bupivacaine/meloxicam)
What this could lead to: If it works, this could offer a way to manage pain after hernia surgery with fewer opioids, reducing addiction risk.
What could go wrong: This is an early Phase 2 trial with only 63 people, so results may not apply to everyone. The drug's safety and effectiveness are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hernia Hernia, Inguinal Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE PAIN

Contacts and locations

Locations

Anaheim Clinical Trials, LLC

Anaheim, California, 92801, United States
JBR Clinical Research

Draper, Utah, 84020, United States
JBR Clinical Research

Murray, Utah, 84107, United States
JBR Clinical Research

Salt Lake City, Utah, 84124, United States
Lotus Clinical Research, LLC

Pasadena, California, 91105, United States

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