New drug cocktail aims to slash opioid use after hernia surgery
NCT ID NCT03695367
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tested a drug called HTX-011 (a mix of bupivacaine and meloxicam) in 63 adults having open inguinal hernia repair. The goal was to see if this painkiller combo, along with other non-opioid medicines, could reduce the need for opioid painkillers after surgery. The study is complete, and researchers measured how many people needed no opioids at all.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
HTX-011 (bupivacaine/meloxicam)
What this could lead to
If it works, this could offer a way to manage pain after hernia surgery with fewer opioids, reducing addiction risk.
What could go wrong
This is an early Phase 2 trial with only 63 people, so results may not apply to everyone. The drug's safety and effectiveness are still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Anaheim Clinical Trials, LLC
Anaheim, California, 92801, United States
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JBR Clinical Research
Draper, Utah, 84020, United States
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JBR Clinical Research
Murray, Utah, 84107, United States
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JBR Clinical Research
Salt Lake City, Utah, 84124, United States
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Lotus Clinical Research, LLC
Pasadena, California, 91105, United States