New injection could ease Post-Surgery pain without opioids

NCT ID NCT02689258

Completed Symptom relief Sponsor: Heron Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tested two experimental drugs, HTX-011 and HTX-002, for pain relief after abdominoplasty (tummy tuck) surgery. 277 adults received an injection of the drug or a placebo. The main goal was to measure pain intensity over the first 24 hours. The study is now complete, and results will show if these drugs offer better pain control than standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HTX-011 (bupivacaine/meloxicam injection)
What this could lead to: If it works, this could provide longer-lasting pain relief after surgery, reducing the need for opioid painkillers.
What could go wrong: This is an early phase 2 trial, so results may not confirm effectiveness. Pain relief varies by person, and side effects like nausea or injection-site reactions are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE PAIN

Contacts and locations

Locations

Study site

Phoenix, Arizona, 85023, United States
Study site

Pasadena, California, 91105, United States
Study site

Pasadena, Maryland, 21122, United States
Study site

Bellaire, Texas, 77401, United States
Study site

Houston, Texas, 77004, United States
Study site

Houston, Texas, 77019, United States
Study site

Houston, Texas, 77027, United States
Study site

Plano, Texas, 75093, United States

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