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New shot may ease knee surgery pain, cut opioid use

NCT ID NCT03015532

Completed Symptom relief Sponsor: Heron Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new pain-relieving medicine called HTX-011 in 285 people having knee replacement surgery. The medicine was injected into the surgical area to see if it could reduce pain and the need for strong opioid painkillers. The goal was to find a safer, more effective way to manage pain after surgery.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE PAIN

Contacts and locations

Locations

  • Study site

    Mobile, Alabama, 36608, United States

  • Study site

    Sheffield, Alabama, 35660, United States

  • Study site

    Phoenix, Arizona, 85015, United States

  • Study site

    Phoenix, Arizona, 85023, United States

  • Study site

    La Jolla, California, 92037, United States

  • Study site

    Riverside, California, 92503, United States

  • Study site

    San Diego, California, 92103, United States

  • Study site

    Miami, Florida, 33136, United States

  • Study site

    Miami, Florida, 33143, United States

  • Study site

    Miami, Florida, 33155, United States

  • Study site

    Tamarac, Florida, 33321, United States

  • Study site

    Las Vegas, Nevada, 89109, United States

  • Study site

    Columbus, Ohio, 43203, United States

  • Study site

    Columbus, Ohio, 43210, United States

  • Study site

    Dayton, Ohio, 45417, United States

  • Study site

    Bellaire, Texas, 77401, United States

  • Study site

    Houston, Texas, 77004, United States

  • Study site

    Houston, Texas, 77027, United States

  • Study site

    Houston, Texas, 77043, United States

  • Study site

    Plano, Texas, 75093, United States

  • Study site

    San Antonio, Texas, 78209, United States

  • Study site

    San Antonio, Texas, 78229, United States

  • Study site

    San Antonio, Texas, 78240, United States

  • Study site

    Webster, Texas, 77598, United States

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