Exercise plus hormone therapy may cut heart risk in menopause

NCT ID NCT05831709

Recruiting now Disease control Sponsor: University Hospital, Ghent Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether combining hormone replacement therapy with a supervised exercise program can improve body composition, heart health, and insulin sensitivity in postmenopausal women. Researchers will follow 390 women over 24 weeks, measuring changes in cardiovascular risk, insulin sensitivity, and body composition. The goal is to see if this combination offers better health outcomes than either approach alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hormonal substitution therapy (hormone replacement therapy) and supervised exercise program
What this could lead to: If successful, this could show that combining hormone therapy with exercise helps manage menopause-related health risks like heart disease and diabetes.
What could go wrong: This is an early-stage observational study, not a treatment trial. Results may not lead to a new therapy, and individual responses to hormones and exercise vary.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENOPAUSAL COMPLAINTS POSTMENOPAUSE

Contacts and locations

Locations

Ghent University Hospital - Women's Clinic
RECRUITING

Ghent, 9000, Belgium

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