Could a common cholesterol drug make menopause hormone therapy safer?
NCT ID NCT07742488
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This study looks at whether adding a statin—a common cholesterol-lowering drug—can reverse blood-clotting changes caused by hormone replacement therapy (HRT) in menopausal women with high cholesterol. Women aged 45 to 55 who need HRT for menopausal symptoms and have high LDL cholesterol will be followed for a year. The researchers will compare blood clotting and inflammation markers in women taking HRT alone versus those who also start a statin after three months, to see if the combination improves the risk profile for blood clots.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Statin (HMG-CoA reductase inhibitor) added to hormone replacement therapy (estroprogestins)
- What this could lead to
- If statins reverse the blood-clotting changes caused by hormone therapy, this could lower the risk of dangerous blood clots in menopausal women taking HRT.
- What could go wrong
- This is a small observational study, so results may not apply broadly. The combination might not improve clotting profiles or could affect liver function, which the study will monitor.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Santa Chiara Hospital - University Hospital of Pisa
RECRUITINGPisa, Italy, 56126, Italy
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