Experimental IDH drug trial halted early – what we know so far
NCT ID NCT04764474
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tested an experimental drug called HMPL-306 in 46 adults with advanced blood cancers (like leukemia) that have a specific genetic change called an IDH mutation. The goal was to find a safe dose and check for side effects. The study was stopped early, so results are limited, but it may help guide future research.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Clinica Universidad de Navarra
Pamplona, Navarre, 31008, Spain
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Froedtert-Medical College of WI
Milwaukee, Wisconsin, 53226, United States
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Hospital Clinico Universitario de Valencia
Valencia, Valencia, 46010, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario La Fe
Valencia, Valencia, 46026, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario de Salamanca
Salamanca, 58-182, Spain
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Institut Catala d'Oncologia de l'Hospitalet de Llobregat - Hospital Duran i Reynals
Barcelona, 08908, Spain
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08901, United States
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START Madrid - Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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The Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center
Orange, California, 92868, United States
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University of Massachusetts Medical School
Worcester, Massachusetts, 01655, United States
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Winship Cancer Institute - Emory University
Atlanta, Georgia, 30322, United States