HMB and exercise: a closer look at muscle building

NCT ID NCT05444959

Completed Knowledge-focused Sponsor: Poznan University of Physical Education Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how a supplement called HMB, combined with exercise, affects muscle proteins and fitness in two groups: trained athletes and people who are not very active or are malnourished. Over 21 days, participants took HMB or a placebo and underwent exercise tests. The goal was to measure changes in muscle-building signals and hormone levels, not to treat a disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: beta-hydroxy-beta-methylbutyric acid (HMB) free acid supplement
What this could lead to: If successful, this could help explain how HMB and exercise together influence muscle building and fitness, potentially guiding future sports nutrition or recovery strategies.
What could go wrong: This is a small, early-stage study focused on biological markers, not clinical outcomes. Results may not translate to real-world benefits or apply to broader populations.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AEROBIC CAPACITY FAT FREE MASS PROTEIN KINASES SPORT SPORTS DIETETICS SPORTS NUTRITION SUPPLEMENTATION

Contacts and locations

Locations

Department of Physiology and Biochemisty at the Faculty of Physical Education and Sport (Charles University, Prague, Czech Republic)

Prague, Prague 6, 162 52, Czechia
Department of Sports Dietetics, Poznan University of Physical Education

Poznan, Wielkopolska, 61-871, Poland

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