New hope for NF1 patients: experimental drug targets painful nerve tumors
NCT ID NCT06541847
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests an oral drug called HLX-1502 in people aged 12 and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas—nerve tumors that can cause pain, disfigurement, or other problems. The study will enroll 25 participants and measure whether the drug can shrink tumors by at least 20% on MRI scans. It is open-label, meaning everyone knows they are getting the drug, and there is no placebo group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
HLX-1502 (an oral drug taken three times daily)
What this could lead to
If successful, this could point toward a new treatment option to shrink or control plexiform neurofibromas in people with NF1.
What could go wrong
This is an early-phase, small study with no placebo group, so results may not be definitive. The drug may cause side effects or fail to show benefit.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for NEUROFIBROMATOSIS TYPE 1 are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Email: •••••@•••••
Locations
-
Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
Contact
Contact
Contact
Contact Email: •••••@•••••
Contact
Contact
-
Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
Contact
Contact
Contact
Contact Email: •••••@•••••
Contact
-
Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
Contact
Contact
Contact
Contact
Contact
Contact
Contact Email: •••••@•••••
Contact
Contact
Contact
Contact
-
Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact Email: •••••@•••••
Contact
-
Children's National Hospital
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact
Contact
Contact
Contact
Contact
Contact Email: •••••@•••••
Contact
Contact
Contact
Contact
-
Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact Email: •••••@•••••
Contact
Contact
Contact
Contact
Contact
Contact
Contact
-
Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact
Contact
Contact
Contact Email: •••••@•••••
Contact
Contact
-
Johns Hopkins Hospital
RECRUITINGBaltimore, Maryland, 21287, United States
Contact
Contact
Contact Email: •••••@•••••
Contact
Contact
-
New York University Langone Health
RECRUITINGNew York, New York, 10016, United States
Contact Email: •••••@•••••
Contact
Contact
Contact
Contact
-
Stanford University
RECRUITINGPalo Alto, California, 94304, United States
Contact
Contact Email: •••••@•••••
Contact
Contact
Contact
-
University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
Contact Email: •••••@•••••
Contact
Contact
-
University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
Contact Email: •••••@•••••
Contact
Contact
-
University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact Email: •••••@•••••
-
Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact
Contact
Contact
Contact
Contact
Contact
Contact Email: •••••@•••••
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact