New HIV vaccine duo enters first human safety trial

NCT ID NCT06919016

Ongoing ⭐️ VACCINE ⭐️ Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial is testing two experimental HIV vaccines, DV700P-RNA and DV701B1.1-RNA, for the first time in people. The study will enroll 45 healthy adults without HIV to check if the vaccines are safe and whether they trigger an immune response. Participants will receive a prime shot followed by a booster, and researchers will monitor side effects and immune system activity over about 16 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Two experimental HIV vaccines: DV700P-RNA (prime) and DV701B1.1-RNA (boost)
What this could lead to: If successful, this could point toward a safe and effective HIV vaccine strategy that trains the immune system to fight the virus.
What could go wrong: This is a very early Phase 1 trial with only 45 people, so it is too soon to know if the vaccines will work. The main goal is safety, not proof of protection against HIV.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV-1-INFECTION

Contacts and locations

Locations

Brigham and Women's Hospital (Site ID: 30007)

Boston, Massachusetts, 02215, United States
Columbia P&S CRS (Site ID: 30329)

New York, New York, 10032, United States
Seattle Vaccine and Prevention CRS (Site ID: 30331)

Seattle, Washington, 98104, United States
The Hope Clinic of the Emory Vaccine Center CRS (Site ID: 31440)

Decatur, Georgia, 30030, United States
University of Alabama Medical Center (Site ID: 31788)

Birmingham, Alabama, 35222, United States
University of Pittsburgh (Site ID: 1001)

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester Medical Center (Site ID: 31467)

Rochester, New York, 14642, United States
Vanderbilt University Medical Center (Site ID: 30352)

Nashville, Tennessee, 37232, United States

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