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Scientists probe cellular signals that may trigger early labor

NCT ID NCT07695467

Knowledge-focused Sponsor: Cumhuriyet University Source: ClinicalTrials.gov ↗

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Registered, but not yet taking participants.
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Stopped early
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Cancelled
Cancelled before anyone took part.

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Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study investigates whether a set of genes and proteins called the Hippo-YAP pathway, along with related microRNAs, are involved in preterm birth. Researchers analyzed blood, placenta, and uterine tissue from women who had cesarean deliveries either at full term or after spontaneous preterm labor. By comparing these samples, they hope to uncover molecular clues that could one day help predict or understand why some babies are born too early.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study finds clear differences in these molecular markers, it could point toward new ways to predict or understand preterm birth.
What could go wrong
This is a small observational study that only looks at samples after delivery. It cannot prove cause and effect, and the findings may not apply to all pregnant women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

44 people

The number who actually took part.

Started

Jun 2021

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pregnant women who underwent cesarean delivery at Sivas Cumhuriyet University Faculty of Medicine and were included in either the spontaneous preterm delivery group or the term delivery comparison group.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- cInclusion Criteria: * Pregnant women aged 18 years or older * Singleton pregnancy * Women who underwent cesarean delivery * For the preterm delivery group: spontaneous preterm labor and delivery between 24 and 34 weeks of gestation * For the term delivery group: cesarean delivery at term gestational age without active labor * Written informed consent for participation and collection of maternal blood, placental tissue, and myometrial tissue samples Exclusion Criteria: * Multiple pregnancy * Major fetal anomaly * Clinical evidence of chorioamnionitis * Hypertensive disorders of pregnancy * Diabetes mellitus or gestational diabetes mellitus * Autoimmune disease * Chronic inflammatory disease * Maternal systemic infection * Placental abruption * Premature rupture of membranes, if excluded in the original protocol * Use of medications or presence of maternal conditions that could significantly affect inflammatory, molecular, or placental biomarker expression * Refusal to provide informed consent Exclusion Criteria: \-

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Conditions

The condition(s) this trial relates to.

Obstetric Labor, Premature Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pregnancy Preterm birth Preterm labor

Contacts and locations

Locations

  • Sivas Cumhuriyet University Faculty of Medicine

    Sivas, Kayseri Ave, 58140, Turkey (Türkiye)

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