Can a week at sea level reset lung pressure for high-altitude dwellers?

NCT ID NCT07804589

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

Researchers are studying healthy adults who live above 2600 meters to see how their lungs respond when they descend to sea level for a week and then return to their usual altitude. The trial measures pulmonary resistance, which is how hard the heart must work to pump blood through the lungs, using echocardiography. The goal is to understand whether a short stay at low altitude changes lung blood pressure upon re-ascent, which could inform travel advice for high-altitude residents.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Re-ascent from sea level to 2850m (behavioral intervention)
What this could lead to
If it works, this could clarify how the lungs adapt to altitude changes, guiding advice for high-altitude residents traveling to lower elevations.
What could go wrong
This is a small observational study with only 14 participants, so results may not apply broadly. It measures short-term effects, not long-term health outcomes.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 14 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-80 years and of all genders * Permanent residence \> 2600 m. * healthy: no self-perceived cardiopulmonary disease limiting daily activities * written informed consent to participate in the study. Exclusion Criteria: * Age \<18 years or \>80 years * Participants who cannot follow the study investigations * Participants permanently living \< 2600m. * Participants who traveled and stayed overnight at altitudes \<2000 m in the past 4 weeks. * any self-perceived cardiopulmonary disease limiting daily activities

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • University Hospital of Zurich

    Zurich, 8091, Switzerland

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