New study tests best way to treat dangerous lung clots

NCT ID NCT04790370

First seen Oct 01, 2025 · Last updated May 16, 2026 · Updated 32 times

Summary

This study compares two treatments for people with a serious type of blood clot in the lungs (pulmonary embolism). Half of the 544 participants will receive standard blood thinners, while the other half will get blood thinners plus a special device that uses ultrasound to help dissolve the clot. The goal is to see which approach better reduces the risk of death and other serious complications over 12 months.

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Contacts and locations

Locations

  • A.o. LKH Univ.-Kliniken Innsbruck

    Innsbruck, Austria

  • Allgemeines Krankenhaus AKH

    Vienna, Austria

  • Augusta University

    Augusta, Georgia, 30904, United States

  • Austria Klinik Ottakring Vienna

    Vienna, Austria

  • Baptist Health East Louisville

    Lousville, Kentucky, 40207, United States

  • CHU (Nimes Cedex)

    Nîmes, France

  • CHU de Besancon

    Besançon, France

  • Cedars - Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Centre Hospitalier Universitaire Vaudois

    Lausanne, Switzerland

  • Christiana Hospital

    Newark, Delaware, 19718, United States

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire, 03756, United States

  • Emory University Hospital

    Atlanta, Georgia, 30322, United States

  • GFO Kliniken Bonn

    Bonn, Germany

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Houston Methodist Sugarland Hospital

    Houston, Texas, 77479, United States

  • Hôpital Européen Georges Pompidou (HEGP)

    Paris, France

  • Johannes Gutenberg Universitaet Mainz

    Mainz, Germany

  • John Paul II Hospital

    Krakow, Poland

  • Kettering Health

    Kettering, Ohio, 45429, United States

  • Klinik Immenstadt

    Immenstädt, Germany

  • Klinikum Bielefeld

    Bielefeld, Germany

  • Klinikum Chemnitz

    Chemnitz, Germany

  • Klinikum Rechts der Isar

    Munich, Germany

  • Leiden University Medical Center

    Leiden, Netherlands

  • Lenox Hill Hospital

    New York, New York, 10075, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mater Misericordiae University Hospital

    Dublin, Ireland

  • Medical University of Warsaw

    Warsaw, Poland

  • Methodist Hospitals

    Merrillville, Indiana, 46410, United States

  • Mount Sinai Medical Center

    New York, New York, 10029, United States

  • Nebraska Methodist Hospital

    Omaha, Nebraska, 68114, United States

  • Newark Beth Israel Medical Center

    Newark, New Jersey, 07112, United States

  • North Mississippi Medical Center

    Tupelo, Mississippi, 38801, United States

  • Northwick Park Hospital

    Middlesex, United Kingdom

  • Piedmont Hospital

    Atlanta, Georgia, 30309, United States

  • Seton Medical Center

    Austin, Texas, 78705, United States

  • St. Antonius Ziekenhuis

    Nieuwegein, Netherlands

  • The Heart Hospital Baylor Plano

    Plano, Texas, 75093, United States

  • The Royal Free Hospital

    London, United Kingdom

  • Uniklinik Aachen

    Aachen, Germany

  • Universitaetsklinikum Freiburg

    Freiburg im Breisgau, Germany

  • Universitaetsklinikum Schleswig-Holstein

    Lübeck, Germany

  • Universitaetsklinikum Tuebingen

    Tübingen, Germany

  • Universitaetsklinikum Wuerzburg

    Würzburg, Germany

  • Universitair Medisch Centrum

    Utrecht, Netherlands

  • University Hospital Basel

    Basel, Switzerland

  • University Hospital Galway

    Galway, Ireland

  • University Hospital Zurich

    Zurich, Switzerland

  • University Hospital of Wales

    Cardiff, United Kingdom

  • University Hospitals of Cleveland

    Cleveland, Ohio, 44106, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • University of Maryland School of Medicine

    Baltimore, Maryland, 21201, United States

  • University of Michigan Hospitals

    Ann Arbor, Michigan, 48109, United States

  • University of Virginia Medical Center

    Charlottesville, Virginia, 22908, United States

  • University of Wisconsin Hospitals

    Madison, Wisconsin, 53792, United States

  • Universitätsklinikum St. Pölten

    Sankt Pölten, Austria

  • Uniwersytecki Szpital Kliniczny w Poznaniu

    Poznan, Poland

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Wellmont Holston Valley Medical Center

    Kingsport, Tennessee, 37660, United States

Conditions

Explore the condition pages connected to this study.