Which breathing aid keeps patients off the ventilator longer?
NCT ID NCT06918288
First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time
Summary
This trial compares two types of breathing support given right after a breathing tube is removed in patients over 50 with type II respiratory failure who had difficulty weaning from a ventilator. One method delivers warm, moist oxygen through small nasal prongs, while the other uses a mask to provide positive-pressure support. The goal is to see which approach better prevents the need for reintubation within 72 hours and 7 days after extubation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- High-Flow Nasal Cannula (HFNC) and Non-Invasive Ventilation (NIV) devices
- What this could lead to
- If one approach proves better, it could reduce the need for reintubation and improve recovery in patients with type II respiratory failure after breathing-tube removal.
- What could go wrong
- This is a single-center trial, and results may not apply to all patients. Both devices have limitations, and individual responses can vary, so neither may clearly outperform the other.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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200 people
The number who actually took part.
- Started
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Apr 2025
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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51 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age \>50 years. * Type II respiratory failure. * Receiving invasive mechanical ventilation. * Difficult weaning from invasive mechanical ventilation, defined as failure to wean after 3-7 days of weaning attempts. * Fulfillment of predefined clinical criteria for extubation. * Written informed consent. Exclusion Criteria: * Refusal to participate or absence of informed consent. * Contraindication to NIV, including hemodynamic instability, excessive respiratory secretions with poor expectoration ability, oral or facial trauma, or recent esophageal surgery. * Poor short-term prognosis, including a very high risk of death within 7 days or receipt of palliative care. * Severe failure of another organ system, including severe cardiac, neurological, renal, or hepatic failure. * Existing tracheostomy. * Loss to follow-up resulting in uncertain 28-day survival.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Benha University Hospital
Banhā, Qalyubia Governorate, 13511, Egypt
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