Cure My Disease

Don't miss your cure!

 Log in / Sign up

Herbal mix challenges standard drug for leg vein relief

NCT ID NCT06579482

Symptom relief Sponsor: Fundação Educacional Serra dos Órgãos Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a combination of herbal ingredients (horse chestnut, polygonum acre, smilax pepyracea, and rutin) works as well as a standard drug (diosmin and hesperidin) for easing leg symptoms from chronic venous insufficiency. 120 adults with mild to moderate vein disease took one of the two treatments for 3 months. The main goal was to see if the herbal blend was not inferior in reducing leg pain, heaviness, and swelling.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
herbal blend (horse chestnut, polygonum acre, smilax pepyracea, rutin)
What this could lead to
If it works, this could offer a natural alternative to standard drugs for relieving heavy, painful legs from vein disease.
What could go wrong
This is a small, completed Phase 4 trial with only 120 participants. The herbal blend may not be as effective as the standard treatment, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

120 people

The number who actually took part.

Started

Nov 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient presenting CEAP classification from grade C0 to C3 in the evaluation of venous disease of the lower limbs 2. Clinical symptoms of chronic venous insufficiency of the lower limbs, defined by the 100mm visual scale performed by the patient between 20mm and 60mm in the most symptomatic lower limb. 3. For female patients of reproductive age, not pregnant or breastfeeding, using reliable contraceptives. 4. Patient read, understood, signed and dated the free and informed consent form Exclusion Criteria: 1. Treatment with compression stockings within 2 months of study inclusion date 2. Treatment with venotonics within 2 months of the date of inclusion in the study 3. Women of reproductive age who are pregnant or breastfeeding, or who do not wish to use contraception during the study period. 4. Known allergy or hypersensitivity to any component of the study drug 5. Known significant laboratory abnormality 6. CEAP Grade Assessment of level 4, 5, or 6. 7. Patient with venous disease requiring intravenous chemical surgery/sclerotherapy 8. Patient presenting with a painful pathology in addition to venous pain in the lower limbs 9. Patient with a history of thrombosis or thromboembolic disease within 6 months of the date of inclusion in the study 10\. Patient with a change in general condition that is incompatible with his/her participation in the study 11. Patient who wishes to become pregnant within 6 months

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Chronic venous insufficiency are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

chronic venous insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic venous insufficiency

Contacts and locations

Locations

  • Centro Universitário Serra dos Órgãos - UNIFESO

    Teresópolis, Rio de Janeiro, 25964004, Brazil

More trials for these conditions

Other studies related to the condition(s) this trial covers.