Herbal mix challenges standard drug for leg vein relief

NCT ID NCT06579482

Completed Symptom relief Sponsor: Fundação Educacional Serra dos Órgãos Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a combination of herbal ingredients (horse chestnut, polygonum acre, smilax pepyracea, and rutin) works as well as a standard drug (diosmin and hesperidin) for easing leg symptoms from chronic venous insufficiency. 120 adults with mild to moderate vein disease took one of the two treatments for 3 months. The main goal was to see if the herbal blend was not inferior in reducing leg pain, heaviness, and swelling.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: herbal blend (horse chestnut, polygonum acre, smilax pepyracea, rutin)
What this could lead to: If it works, this could offer a natural alternative to standard drugs for relieving heavy, painful legs from vein disease.
What could go wrong: This is a small, completed Phase 4 trial with only 120 participants. The herbal blend may not be as effective as the standard treatment, and results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

chronic venous insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC VENOUS INSUFFICIENCY

Contacts and locations

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Locations

Centro Universitário Serra dos Órgãos - UNIFESO

Teresópolis, Rio de Janeiro, 25964004, Brazil

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