New combo therapy aims to fight deadly breast cancer spread to the brain
NCT ID NCT04588545
First seen Nov 15, 2025 · Last updated May 14, 2026 · Updated 20 times
Summary
This study tests if radiation therapy followed by two targeted drugs (trastuzumab and pertuzumab) given directly into the spinal fluid is safe and helps people with HER2+ breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). About 39 participants will receive increasing doses of pertuzumab with a fixed dose of trastuzumab. The goal is to find the best dose and see if it improves survival.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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Northwestern University
RECRUITINGEvanston, Illinois, 60208, United States
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