Breakthrough trial aims to free hepatitis b patients from lifelong medication

NCT ID NCT05630807

Ongoing ⭐️ CURE ⭐️ Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

Summary

This large Phase 3 study is testing whether an investigational drug called bepirovirsen can provide a 'functional cure' for people with chronic Hepatitis B. It involves nearly 1,000 participants who are already on standard antiviral medication. The main goal is to see if adding bepirovirsen for 24 weeks can suppress the virus enough that patients can safely stop all treatments and remain healthy long-term.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

GSK Investigational Site

Chandler, Arizona, 85224, United States
GSK Investigational Site

Davis, California, 95817, United States
GSK Investigational Site

Los Angeles, California, 90027, United States
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Palo Alto, California, 94304, United States
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San Jose, California, 95128, United States
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Littleton, Colorado, 80120, United States
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Miami, Florida, 33134, United States
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Iowa City, Iowa, 52242, United States
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Baltimore, Maryland, 21287, United States
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Detroit, Michigan, 48377, United States
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Richmond, Virginia, 23219, United States
GSK Investigational Site

Richmond, Virginia, 23249, United States
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Buenos Aires, 1061, Argentina
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Buenos Aires, C1061AAS, Argentina
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Buenos Aires, C1125ABE, Argentina
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Capital Federal, C1181ACI, Argentina
GSK Investigational Site

Pilar, B1629AHJ, Argentina
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Rosario, S2002KDT, Argentina
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Aracaju, 49060-010, Brazil
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Campinas, 13034-685, Brazil
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Curitiba, 80810-050, Brazil
GSK Investigational Site

Manaus, 69040-000, Brazil
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Porto Alegre, 90035003, Brazil
GSK Investigational Site

Santa Maria, 97105-900, Brazil
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São Paulo, 05403-000, Brazil
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São Paulo, 08270-070, Brazil
GSK Investigational Site

Vila Mariana, 04121-000, Brazil
GSK Investigational Site

Sofia, 1431, Bulgaria
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Sofia, 1606, Bulgaria
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Sofia, Bulgaria
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Veliko Tarnovo, 5000, Bulgaria
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Vancouver, British Columbia, V6Z 2K5, Canada
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Victoria, British Columbia, V8V 3M9, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1V 4G2, Canada
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Saint-Jérôme, Quebec, J7Z 2V4, Canada
GSK Investigational Site

Beijing, 100015, China
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Beijing, 100050, China
GSK Investigational Site

Beijing, China
GSK Investigational Site

Changchun, 130021, China
GSK Investigational Site

Chengdu, China
GSK Investigational Site

Chongqing, 400042, China
GSK Investigational Site

Fuzhou, 350025, China
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Guangzhou, 510060, China
GSK Investigational Site

Guangzhou, 510515, China
GSK Investigational Site

Guangzhou, 510630, China
GSK Investigational Site

Hangzhou, 310000, China
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Hangzhou, 310003, China
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Kunming, 650021, China
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Nanjing, 210008, China
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Shanghai, 200025, China
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Shanghai, 200040, China
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Shanghai, 201506, China
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Shenyang, 110022, China
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Shenzhen, 518023, China
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Ürümqi, 830054, China
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Wuhan, 430022, China
GSK Investigational Site

Xi'an, 710061, China
GSK Investigational Site

Zhengzhou, 450000, China
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Zhenjiang, China
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Clermont-Ferrand, 63003, France
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Clichy, 92118, France
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Dijon, 21079, France
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Lille, 59037, France
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Pessac, 33604, France
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Poitiers, 86021, France
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Rennes, 35033, France
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Strasbourg, 67091, France
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Toulouse, 31059, France
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Berlin, 10243, Germany
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Berlin, 10439, Germany
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Berlin, 10787, Germany
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Berlin, 12163, Germany
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Bochum, 44787, Germany
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Cologne, 50668, Germany
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Düsseldorf, 40225, Germany
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München, 80336, Germany
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Athens, 10676, Greece
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Athens, 11527, Greece
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Periohi Dragana Alexand, 68100, Greece
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Rio Patras, 26504, Greece
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Kowloon, Hong Kong
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Pokfulam, Hong Kong
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Shatin, Hong Kong
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Budapest, 1097, Hungary
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Eger, 3300, Hungary
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Gyula, 5700, Hungary
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Miskolc, 3530, Hungary
GSK Investigational Site

Belagavi, 590010, India
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Chandigarh, 160012, India
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Chennai, 600113, India
GSK Investigational Site

Coimbatore, 641005, India
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Guhawati, 781006, India
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Hyderabad, 500033, India
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HyderabadTelangana, 500048, India
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Jaipur, 302001, India
GSK Investigational Site

Ludhiana, 141001, India
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Manipal, 576104, India
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Mumbai, 400 008, India
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Mumbai, 400012, India
GSK Investigational Site

Mumbai, 400026, India
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Pune, 411001, India
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Surat, 395002, India
GSK Investigational Site

Brescia, 25123, Italy
GSK Investigational Site

Foggia, 71100, Italy
GSK Investigational Site

Messina, 98124, Italy
GSK Investigational Site

Milan, 20122, Italy
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Milan, 20162, Italy
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Modena, 40126, Italy
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Chiba, 272-8516, Japan
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Ehime, 790-8524, Japan
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Fukuoka, 820-8505, Japan
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Fukuoka, 839-0863, Japan
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Gifu, 500-8717, Japan
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Gifu, 503-8502, Japan
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Hiroshima, 734-8551, Japan
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Hiroshima, 737-0023, Japan
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Hokkaido, 053-8506, Japan
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Hyōgo, 660-8550, Japan
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Kumamoto, 862-8655, Japan
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Miyagi, 980-8574, Japan
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Tokyo, 113-8519, Japan
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Tokyo, 173-8610, Japan
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Tokyo, 180-8610, Japan
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George Town, Malaysia
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Johor Bahru, 80100, Malaysia
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Kota Bharu Kelantan, Malaysia
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Kota Kinabalu, Malaysia
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Kuala Lumpur, Malaysia
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Kuantan, Malaysia
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Guadalajara, 44160, Mexico
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Oaxaca City, 68000, Mexico
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Panama City, 07206, Panama
GSK Investigational Site

Bytom, 41-902, Poland
GSK Investigational Site

Krakow, 31-202, Poland
GSK Investigational Site

Łańcut, 37-100, Poland
GSK Investigational Site

Bucharest, 021105, Romania
GSK Investigational Site

Bucharest, 20125, Romania
GSK Investigational Site

Cluj-Napoca, 400162, Romania
GSK Investigational Site

Iași, 700116, Romania
GSK Investigational Site

Suceava, 720224, Romania
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Timișoara, 300001, Romania
GSK Investigational Site

Singapore, 119074, Singapore
GSK Investigational Site

Singapore, 169608, Singapore
GSK Investigational Site

Ansan, 15355, South Korea
GSK Investigational Site

Busan, 47392, South Korea
GSK Investigational Site

Daegu, 42601, South Korea
GSK Investigational Site

Daegu, 700-721, South Korea
GSK Investigational Site

Seoul, 03080, South Korea
GSK Investigational Site

Seoul, 06351, South Korea
GSK Investigational Site

Seoul, 07061, South Korea
GSK Investigational Site

Seoul, 08308, South Korea
GSK Investigational Site

Barcelona, 08035, Spain
GSK Investigational Site

Barcelona, 08036, Spain
GSK Investigational Site

León, 24080, Spain
GSK Investigational Site

Madrid, 28041, Spain
GSK Investigational Site

Málaga, 29010, Spain
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Salamanca, 37007, Spain
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Santander, 39008, Spain
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Valencia, 46014, Spain
GSK Investigational Site

Valladolid, 47003, Spain
GSK Investigational Site

Vigo, 36002, Spain
GSK Investigational Site

Kaohsiung City, 807, Taiwan
GSK Investigational Site

Kaohsiung City, 833, Taiwan
GSK Investigational Site

Taichung, 40705, Taiwan
GSK Investigational Site

Taipei, 104, Taiwan
GSK Investigational Site

Tau-Yuan, 333, Taiwan
GSK Investigational Site

Bangkok, 10330, Thailand
GSK Investigational Site

Ankara, 06230, Turkey (Türkiye)
GSK Investigational Site

Birmingham, B15 2TH, United Kingdom
GSK Investigational Site

Edinburgh, EH4 2XU, United Kingdom
GSK Investigational Site

Leeds West Yorkshire, LS9 7TF, United Kingdom
GSK Investigational Site

London, SE5 9RS, United Kingdom
GSK Investigational Site

London, SW17 0QT, United Kingdom

Conditions

Explore the condition pages connected to this study.

CHRONIC HEPATITIS B HEPATITIS B, CHRONIC