Heated chemo could boost ovarian cancer survival

NCT ID NCT05659381

Recruiting now Disease control Sponsor: GOG Foundation Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether giving heated chemotherapy directly into the abdomen during surgery helps people with advanced ovarian, fallopian tube, or primary peritoneal cancer. About 220 participants will be randomly assigned to receive either heated chemo plus standard treatment or standard treatment alone. After surgery, both groups will get maintenance therapy to keep cancer from returning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cisplatin (heated chemotherapy)
What this could lead to: If successful, this could improve how long people with advanced ovarian cancer live without their cancer growing back.
What could go wrong: This is a phase 3 trial, but results are not yet known. The heated chemo may cause more side effects, and not everyone may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer fallopian tube neoplasm ovarian cancer ovarian carcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STAGE III FALLOPIAN TUBE CANCER STAGE III OVARIAN CANCER STAGE III PRIMARY PERITONEAL CANCER STAGE IV FALLOPIAN TUBE CANCER STAGE IV OVARIAN CANCER STAGE IV PRIMARY PERITONEAL CANCER

Contacts and locations

Locations

Asplundh Cancer Pavilion
RECRUITING

Willow Grove, Pennsylvania, 19090, United States
Baylor College of Medicine Medical Center
RECRUITING

Houston, Texas, 77030, United States
City of Hope
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States
Duke Women's Cancer Care Raleigh
RECRUITING

Raleigh, North Carolina, 27607, United States
Forbes Hospital
RECRUITING

Monroeville, Pennsylvania, 15146, United States
Froedtert Memorial Lutheran Hospital & Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06102, United States
Hoag Memorial Hospital Presbyterian
RECRUITING

Newport Beach, California, 92663, United States
Holy Name Medical Center
RECRUITING

Teaneck, New Jersey, 07666, United States
Inova Schar Cancer Institute
RECRUITING

Fairfax, Virginia, 22031, United States
Jefferson Abington Hospital
RECRUITING

Abington, Pennsylvania, 19001, United States
Jefferson Hospital
RECRUITING

Jefferson Hills, Pennsylvania, 15025, United States
LSU Health New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States
Lankenau Medical Center/Mainline Medical Center
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Medical University of South Carolina (Hollings Cancer Center)
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Sloan-Kettering Cancer Center
RECRUITING

New York, New York, 10022, United States
Miami Cancer Institute
RECRUITING

Miami, Florida, 33176, United States
O'Quinn Medical Tower at McNair Campus
RECRUITING

Houston, Texas, 77054, United States
SCC at Lake University
RECRUITING

Mentor, Ohio, 44060, United States
Smilow Cancer Hospital at Yale- New Haven
RECRUITING

New Haven, Connecticut, 06511, United States
St. John Medical Center
RECRUITING

Westlake, Ohio, 44145, United States
Stanford Ambulatory Surgery Center Lane Operating Room
RECRUITING

Palo Alto, California, 94034, United States
Stanford Hospital
RECRUITING

Palo Alto, California, 94305, United States
Stanford Women's Cancer Center
RECRUITING

Palo Alto, California, 94304, United States
Sylvester Comprehensive Cancer Center - Plantation
RECRUITING

Plantation, Florida, 33324, United States
Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center
RECRUITING

Coral Gables, Florida, 33146, United States
Texas Oncology - Central South
RECRUITING

Austin, Texas, 78758, United States
TriHealth Cancer Institute - Good Samaritan Hospital
RECRUITING

Cincinnati, Ohio, 45220, United States
TriHealth Cancer Institute- Thomas Comprehensive Care Center
RECRUITING

Cincinnati, Ohio, 45242, United States
UH Geauga Medical Center
RECRUITING

Chardon, Ohio, 44024, United States
UH Minoff Health Center at Chagrin Highlands
RECRUITING

Orange, Ohio, 44122, United States
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States
University of California San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Colorado Hospital - Anshutz Cancer Pavilion
RECRUITING

Aurora, Colorado, 80045, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center North
RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Cancer Center Westwood
RECRUITING

Westwood, Kansas, 66205, United States
University of Kansas Clinical Research Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Kansas Hospital
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Indian Creek Breast Surgery
RECRUITING

Overland Park, Kansas, 66211, United States
University of Kansas Medical Center MOB
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kentucky Medical Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Miami Hospital and Clinics
RECRUITING

Miami, Florida, 33136, United States
University of Miami Hospital and Clinics - Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States
University of New Mexico Comprehensive Cancer Center
RECRUITING

Albuquerque, New Mexico, 87102, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
West Chester Hospital
RECRUITING

West Chester, Ohio, 45069, United States
West Penn Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Wexford Hospital
RECRUITING

Wexford, Pennsylvania, 15090, United States
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06520, United States

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