Major trial tests drug to keep severe heart failure patients out of hospital

NCT ID NCT06736574

Recruiting now Disease control Sponsor: Cytokinetics Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial is testing whether a new drug called omecamtiv mecarbil can help people with severe heart failure. It aims to see if the drug reduces the risk of serious events like hospitalization, needing a heart device or transplant, or death. About 1,800 participants will be randomly assigned to receive either the new drug or a placebo for up to three years.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A.O. Perugia - Ospedale S.Maria della Misericordia
RECRUITING

Perugia, Province of Perugia, 06129, Italy
AHEPA University General Hospital of Thessaloniki
RECRUITING

Thessaloniki, Thessaloniki, 54636, Greece
AHMG Cardiology and Surgery
RECRUITING

Overland Park, Kansas, 66211, United States
APHP - Hôpital Bichât
RECRUITING

Paris, Île-de-France Region, 75018, France
ASST Papa Giovanni XXIII
RECRUITING

Bergamo, Lombardy, 24127, Italy
ASST Spedali Civili di Brescia
RECRUITING

Brescia, BS, 25123, Italy
Advanced Cardiovascular, LLC
RECRUITING

Alexander City, Alabama, 35010, United States
Advanced Heart Care, LLC
RECRUITING

Bridgewater, New Jersey, 08807, United States
AdventHealth
RECRUITING

Orlando, Florida, 32803, United States
Asklepios Klinik Langen-Seligenstadt GmbH
RECRUITING

Langen, Hesse, 63225, Germany
Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant' Anna
RECRUITING

Cona, 44124, Italy
Balsammedica Sp. z o.o.
RECRUITING

Warsaw, Masovian Voivodeship, 01249, Poland
Basingstoke and North Hampshire Hospital
RECRUITING

Basingstoke, RG249NA, United Kingdom
Baylor Scott & White Medical Center- The Hearth Hospital
RECRUITING

Plano, Texas, 75093, United States
Baylor University Medical Center
RECRUITING

Dallas, Texas, 75246, United States
Broward Research Center
RECRUITING

Miami Beach, Florida, 33140, United States
CHF Heart Clinical (Subject Visits & IP Shipments)
RECRUITING

Clearwater, Florida, 33756, United States
CHI St. Luke's Health Baylor College of Medicine Medical Center
RECRUITING

Houston, Texas, 77030, United States
CHU de Montpellier- Hôpital Arnaud de Villeneuve
RECRUITING

Montpellier, Occitanie, 34295, France
CHU de Rennes - Hôpital Pontchaillou
RECRUITING

Rennes, Ille-et-Vilaine, 35033, France
CHUVI - H.U. Alvaro Cunqueiro
RECRUITING

Vigo, Pontevedra, 36312, Spain
CISSSL - Hopital Pierre-Le Gardeur
RECRUITING

Terrebonne, Quebec, J6V 2H2, Canada
California Pacific Medical Center Van Ness Campus
RECRUITING

San Francisco, California, 94109, United States
Capital Area Research, LLC
RECRUITING

Camp Hill, Pennsylvania, 17011, United States
Capital Cardiology Associates
RECRUITING

Albany, New York, 12205, United States
Cardiology Associates of Fairfield County, P.C
RECRUITING

Bridgeport, Connecticut, 06606, United States
Cardiovascular Research of Northwest Indiana, LLC.
RECRUITING

Munster, Indiana, 46321, United States
Castle Hill Hospital
RECRUITING

Cottingham, HU165JQ, United Kingdom
Centralny Szpital Kliniczny UCK WUM
RECRUITING

Warsaw, Masovian Voivodeship, 02-097, Poland
Centre Hospitalier Intercommunal Toulon - La Seyne sur Mer (C.H.I.T.S)
RECRUITING

Toulon, Var, 83100, France
Centre Hospitalier Universitaire Grenoble Alpes - Site Nord Michallon
RECRUITING

La Tronche, Isère, 38700, France
Centre Hospitalier Universitaire de Toulouse
RECRUITING

Toulouse, Haute-Garonne, 31059, France
Centro Cardiologico Monzino
RECRUITING

Milan, Lombardy, 20138, Italy
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Clinical and Translational Research Center - University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599-7064, United States
Columbia University Medical Center / New York - Presbyterian
RECRUITING

New York, New York, 10032, United States
Deaconess Heart Group
RECRUITING

Newburgh, Indiana, 47630, United States
Diex Recherche Sherbrooke
RECRUITING

Sherbrooke, Quebec, J1L0H8, Canada
Dr. med. Jens Taggeselle
RECRUITING

Markkleeberg, Saxony, 04416, Germany
Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
Eastern Main Medical Center dba Northern Light Eastern Maine Medical Center
RECRUITING

Bangor, Maine, 04401, United States
Emory Clinic
RECRUITING

Atlanta, Georgia, 30322, United States
General Hospital ''Asklepieio Voulas''
RECRUITING

Voula, Attica, 16673, Greece
General Hospital of Athens ''G. Gennimatas''
RECRUITING

Athens, Attica, 11527, Greece
General Hospital of Athens ''Hippokratio''
RECRUITING

Athens, Attica, 11527, Greece
General Hospital of Nea Ionia ''Konstantopouleio-Patision''
RECRUITING

Athens, Attica, 14233, Greece
Glasgow Royal Infirmary
RECRUITING

Glasgow, G40SF, United Kingdom
Grady Health System
RECRUITING

Atlanta, Georgia, 30303, United States
Great Western Hospitals
RECRUITING

Swindon, SN36BB, United Kingdom
Harefield Hospital
RECRUITING

Harefield, Greater London, UB96JH, United Kingdom
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06102, United States
Helios Klinikum Erfurt GmbH
RECRUITING

Erfurt, Germany, 99089, Germany
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Holy Cross Medical Group - Cardiology Associates
RECRUITING

Fort Lauderdale, Florida, 33308, United States
Hospital Clinico Universitario de Santiago
RECRUITING

Santiago de Compostela, A Coruña, 15706, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, Valencia, 46010, Spain
Hospital San Juan de la Cruz
RECRUITING

Úbeda, Jaen, 23400, Spain
Hospital Universitari Joan XXIII de Tarragona
RECRUITING

Tarragona, Tarragona, 43005, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona, 08035, Spain
Hospital Universitari de Bellvitge
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital Universitari i Politecnic La Fe de Valencia
RECRUITING

Valencia, Valencia, 46026, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Madrid, 28041, Spain
Hospital Universitario A Coruña
RECRUITING

A Coruña, A Coruña, 15006, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, Madrid, 28046, Spain
Hospital Universitario Lucus Augusti
RECRUITING

Lugo, Lugo, 27003, Spain
Hospital Universitario Puerta de Hierro
RECRUITING

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Virgen de La Arrixaca
RECRUITING

El Palmar, Murcia, 30120, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, Sevilla, 41013, Spain
Hospital Universitario de Salamanca
RECRUITING

Salamanca, Salamanca, 37007, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, Barcelona, 08025, Spain
Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Hôpital Européen Georges Pompidou
RECRUITING

Paris, Île-de-France Region, 75015, France
Hôpital Lariboisière - APHP
RECRUITING

Paris, Île-de-France Region, 75010, France
IRCCS Multimedica
RECRUITING

Sesto San Giovanni, Lombardy, 20099, Italy
IRCCS Ospedale San Raffaele
RECRUITING

Milan, MI, 20132, Italy
IRCCS San Raffaele
RECRUITING

Roma, 00163, Italy
Intermountain Medical Center
RECRUITING

Murray, Utah, 84107, United States
K&R Research LLC
WITHDRAWN

Marion, Ohio, 43302, United States
Kaiser Permanente Santa Clara
RECRUITING

Santa Clara, California, 95051, United States
Keck Medical Center of USC (outpatient clinic)
RECRUITING

Los Angeles, California, 90033, United States
Kelowna General Hospital
RECRUITING

Kelowna, British Columbia, V1Y1T2, Canada
Kerckhoff-Klinik GmbH
RECRUITING

Bad Nauheim, Hesse, 61231, Germany
Kingston Health Sciences Centre
RECRUITING

Kingston, Ontario, K7L 2V7, Canada
Krakowski Szpital Specjalistyczny im. Sw. Jana Pawla II
RECRUITING

Krakow, 31202, Poland
L'Hôpital Privé Du Confluent
RECRUITING

Nantes, Pays de la Loire Region, 44277, France
LMU Klinikum - Medizinische Klinik und Poliklinik I
RECRUITING

München, Bavaria, 81377, Germany
London Health Sciences Centre
RECRUITING

London, Ontario, N6A5A5, Canada
Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center
RECRUITING

Torrance, California, 90502, United States
Marienhaus Klinikum Mainz GmbH
RECRUITING

Mainz, Germany, 55131, Germany
Mazankowski Alberta Heart Institute / University of Alberta Hospital
RECRUITING

Edmonton, Alberta, T6G2B7, Canada
Medical College of Wisconsin / Froedtert Hospital
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina - Gazes Research Institute
RECRUITING

Charleston, South Carolina, 29425, United States
Medresearch Inc
RECRUITING

El Paso, Texas, 79902, United States
Midwest Cardiovascular Institute
RECRUITING

Naperville, Illinois, 60540, United States
Midwest Heart and Vascular Specialists, LLC
RECRUITING

Independence, Missouri, 64057, United States
Monmouth Cardiology Associates, LLC
RECRUITING

Eatontown, New Jersey, 07724, United States
Montefiore Medical Center (Moses Campus)
RECRUITING

The Bronx, New York, 10467, United States
Montreal Heart Institute
RECRUITING

Montreal, Quebec, H1T1C8, Canada
Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc.
RECRUITING

Rapid City, South Dakota, 57701, United States
Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health
RECRUITING

Greensboro, North Carolina, 27401, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
National Heart Institute
RECRUITING

Beverly Hills, California, 90211, United States
Northwell Health North Shore University Hospital
RECRUITING

Manhasset, New York, 11030, United States
Nutrition Research Center (SPH)
RECRUITING

Loma Linda, California, 92350, United States
Oakville Trafalgar Memorial Hospital - Halton Healthcare
RECRUITING

Oakville, Ontario, L6M0L8, Canada
Ocala Cardiovascular Research
RECRUITING

Ocala, Florida, 34471, United States
Oklahoma State University Center for Health Sciences
RECRUITING

Tulsa, Oklahoma, 74127, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Ospedale Infermi
RECRUITING

Rimini, Emilia-Romagna, 47923, Italy
Ospedale di Arzignano
RECRUITING

Arzignano, Lombardy, 36071, Italy
Papageorgiou General Hospital of Thessaloniki
RECRUITING

Efkarpia, Thessaloniki, 56403, Greece
Penn State Health Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
Piedmont Atlanta Hospital
RECRUITING

Atlanta, Georgia, 30309, United States
Piedmont Fayette Hospital
RECRUITING

Fayetteville, Georgia, 30214, United States
Pima Heart and Vascular Clinical Research
WITHDRAWN

Tucson, Arizona, 85741, United States
Polyclinique Vauban
RECRUITING

Valenciennes, Hauts-de-France, 59300, France
Poradnia AKA-MED Centrum Sp. z o.o.
RECRUITING

Ruda Śląska, 41710, Poland
Providence Advanced Heart Disease and Transplant
RECRUITING

Spokane, Washington, 99204, United States
Queen Elizabeth University Hospital
RECRUITING

Glasgow, Scotland, G514TF, United Kingdom
Reid Physician Associates
RECRUITING

Richmond, Indiana, 47374, United States
Rocky Mountain Regional VA Medical Center
RECRUITING

Aurora, Colorado, 80045, United States
Russells Hall Hospital
RECRUITING

Dudley, DY12HQ, United Kingdom
SMH - Cardiology Clinical Trials Inc.
RECRUITING

Surrey, British Columbia, V3V0C6, Canada
SPZOZ Centralny Szpital Kliniczny UM w Lodzi
RECRUITING

Lodz, 92213, Poland
SPZOZ Uniwersytecki Szpital Kliniczny nr 2 UM w Lodzi
RECRUITING

Lodz, 90549, Poland
Saint Luke's Hospital of Kansas City
RECRUITING

Kansas City, Missouri, 64111, United States
San Diego Cardiac Center
RECRUITING

San Diego, California, 92123, United States
Sentara Norfolk General Hospital
RECRUITING

Norfolk, Virginia, 23507, United States
South Florida Research Solutions, LLC
RECRUITING

Hollywood, Florida, 33351, United States
Southampton General Hospital
RECRUITING

Southampton, Hampshire, SO166YD, United Kingdom
St. Boniface Hospital
RECRUITING

Winnipeg, Manitoba, R2H2A6, Canada
St. Louis Heart and Vascular
WITHDRAWN

St Louis, Missouri, 63136, United States
St. Michael's Hospital
RECRUITING

Toronto, Ontario, M5B1W8, Canada
St. Paul's Hospital
RECRUITING

Vancouver, British Columbia, V6Z1Y6, Canada
Stanford University Hospital / Stanford Health Care
RECRUITING

Stanford, California, 94303, United States
Stern Cardiovascular Foundation, Inc.
RECRUITING

Germantown, Tennessee, 38138, United States
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N1J7, Canada
Sutter Institute for Medical Research (SIMR)
RECRUITING

Sacramento, California, 95816, United States
Szpital Sw. Anny w Miechowie
RECRUITING

Miechów, 32200, Poland
Tennessee Center for Clinical Trials
RECRUITING

Tullahoma, Tennessee, 37388, United States
Tennova Healthcare-Turkey Creek Medical Center
RECRUITING

Knoxville, Tennessee, 37934, United States
The Lindner Research Center at the Christ Hospital
RECRUITING

Cincinnati, Ohio, 45219, United States
The Queen's Medical Center - Punchbowl
RECRUITING

Honolulu, Hawaii, 96813, United States
The University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
The University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Tomasz Blicharski Lubelskie Centrum Diagnostyczne
RECRUITING

Świdnik, 21040, Poland
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
UC Davis Health
RECRUITING

Sacramento, California, 95817, United States
UC San Diego Health - Sulpizio Cardiovascular Center
RECRUITING

La Jolla, California, 92037, United States
UCLA Medical Center Cardiovascular Clinic
RECRUITING

Los Angeles, California, 90095, United States
UF Health Jacksonville
RECRUITING

Jacksonville, Florida, 32209, United States
UHN-Toronto General Hospital
RECRUITING

Toronto, Ontario, M5G2C4, Canada
UKE, Klinik fur Kardiologie
RECRUITING

Hamburg, Hamburg, 20246, Germany
UKE, Klinik für Kardiologie
RECRUITING

Hamburg, Hamburg, 20246, Germany
USF Health South Tampa Center for Advanced Healthcare
RECRUITING

Tampa, Florida, 33606, United States
Ulster Hospital
RECRUITING

Dundonald, BT161RH, United Kingdom
Universitaetsklinikum Frankfurt, Med. Klinik III - Kardiologie, Angiologie
RECRUITING

Frankfurt am Main, Hesse, 60590, Germany
Universitaetsklinikum Jena
RECRUITING

Jena, Germany, 07747, Germany
Universitaetsmedizin Goettingen
RECRUITING

Göttingen, Lower Saxony, 37075, Germany
University General Hospital ''ATTIKON'' - General Hospital of West Attica H
RECRUITING

Chaïdári, Attica, 12462, Greece
University General Hospital of Alexandroupolis
RECRUITING

Alexandroupoli, Evros, 68100, Greece
University General Hospital of Larissa
RECRUITING

Larissa, Larissa, 41110, Greece
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of California, Irvine Medical Center
RECRUITING

Orange, California, 92868, United States
University of Hospitals North Ohio Heart
RECRUITING

Sandusky, Ohio, 44870, United States
University of Maryland Medical Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Texas Medical Branch - UTMB
RECRUITING

Galveston, Texas, 77555, United States
University of Utah Health
RECRUITING

Salt Lake City, Utah, 84132, United States
Universitätsklinik Würzburg Deutsches Zentrum für Herzinsuffizienz
RECRUITING

Würzburg, Bavaria, 97078, Germany
Universitätsklinikum Bonn
RECRUITING

Bonn, North Rhine-Westphalia, 53127, Germany
Uniwersytecki Szpital Kliniczny w Bialymstoku
RECRUITING

Bialystok, 15276, Poland
Uniwersytecki Szpital Kliniczny w Opolu
RECRUITING

Opole, 45401, Poland
Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITING

Poznan, 61848, Poland
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Victoria Heart Institute Foundation
RECRUITING

Victoria, British Columbia, V8R1B2, Canada
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
WakeMed Heart & Vascular - Cary Cardiology
RECRUITING

Cary, North Carolina, 27518, United States
Washington University Center for Advanced Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Wojewodzki Szpital Zespolony im. L. Rydygiera
RECRUITING

Torun, 87100, Poland
Yale New Haven Health Heart & Vascular Center Outpatient Services
RECRUITING

New Haven, Connecticut, 06519, United States

Conditions

Explore the condition pages connected to this study.

HEART FAILURE HEART FAILURE WITH REDUCED EJECTION FRACTION