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Paired stimulation plasticity for motor recovery in humans with and without spinal cord injury

NCT ID NCT07814313

NEW Sponsor: Shirley Ryan AbilityLab Source: ClinicalTrials.gov ↗

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Recruiting now This study
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The trial has finished. Results may not be published yet.
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Cancelled before anyone took part.

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First seen Sep 10, 2026 · Last updated Sep 10, 2026

Summary

This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control. The study includes two experiments. Experiment 1 will assess corticospinal and reticulospinal tract transmission to lower-limb muscles in older adults with and without SCI. Experiment 2 will examine how aging and spinal cord injury affect the body's ability to strengthen nerve pathways involved in movement. The investigators will compare two pathways that help control leg movement, the corticospinal and reticulospinal pathways, to determine whether aging affects these pathways differently and whether spinal cord injury has a greater effect on the corticospinal pathway.

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Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Sep 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Vulnerable populations, including children (\<18 years) and pregnant women, will be excluded from this study.

Ages

19 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and females between 19-85 years; * Chronic SCI (≥ 1 years post-injury); * T10 or above - American Spinal Injury Association (AIS) Grade C, or D; * Ability to perform a small voluntary ankle dorsiflexion, knee extension, and ankle plantarflexion (as detected by presence of voluntary EMG activity in the rectus femoris, tibialis anterior, and soleus muscles) with at least one leg; * Ability to tolerate standing position; * Ability to initiate at least one step without the assistance of a therapist; * If ambulatory, ability to walk at a minimum speed of 0.1 m/s on a treadmill. Inclusion criteria for controls: * Male and females (19-85 years); * Able to perform dorsiflexion; * Able to walk. Exclusion Criteria: * Uncontrolled medical problems including pulmonary, cardiovascular, or orthopedic disease; * Any debilitating disease before the SCI that caused exercise intolerance; * Premorbid, ongoing major depression or psychosis, altered cognitive status; * History of head injury or stroke; * Pacemaker; * Metal plate in skull; * History of seizures; * Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold, such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants; * Pregnancy; * Ongoing cord compression or a syrinx in the spinal cord or spinal cord disease, such as spinal stenosis, spina bifida or herniated cervical disk; * implanted defibrillators or implanted neurostimulators; * have large ischaemic scars; * diagnosed sleep deprivation. Exclusion criteria for controls: \- Same as for subjects with SCI.

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy control Spinal cord injury

How to take part

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  1. The places running it

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  2. The official record

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    Open the record ↗

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Contacts and locations

Locations

  • Shirley Ryan Abilitylab

    RECRUITING

    Chicago, Illinois, 60611, United States

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