Immunotherapy vs. standard care: a Head-to-Head cancer trial

NCT ID NCT03258554

Completed Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This trial tested if adding a newer immunotherapy drug (durvalumab) to radiation therapy works better than the standard combination of radiation with an older drug (cetuximab). It was for patients with advanced head and neck cancer who could not safely take the usual chemotherapy drug, cisplatin. The main goals were to see which treatment helped patients live longer without their cancer getting worse and to compare side effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1, Canada
Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States
Allegiance Health

Jackson, Michigan, 49201, United States
Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, 94704, United States
Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States
Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States
Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090, United States
Atrium Health Cabarrus/LCI-Concord

Concord, North Carolina, 28025, United States
Atrium Health Pineville/LCI-Pineville

Charlotte, North Carolina, 28210, United States
Atrium Health Stanly/LCI-Albemarle

Albemarle, North Carolina, 28002, United States
Atrium Health Union/LCI-Union

Monroe, North Carolina, 28112, United States
Augusta University Medical Center

Augusta, Georgia, 30912, United States
Aultman Health Foundation

Canton, Ohio, 44710, United States
Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Banner McKee Medical Center

Loveland, Colorado, 80539, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States
Beebe Health Campus

Rehoboth Beach, Delaware, 19971, United States
Beebe South Coastal Health Campus

Millville, Delaware, 19967, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
CTCA at Western Regional Medical Center

Goodyear, Arizona, 85338, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Chelsea Hospital

Chelsea, Michigan, 48118, United States
Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
City of Hope South Pasadena

South Pasadena, California, 91030, United States
Cleveland Clinic Cancer Center Mansfield

Mansfield, Ohio, 44906, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cleveland Clinic Mercy Hospital

Canton, Ohio, 44708, United States
Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691, United States
Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States
Community Cancer Center East

Indianapolis, Indiana, 46219, United States
Community Cancer Center North

Indianapolis, Indiana, 46256, United States
Community Cancer Center South

Indianapolis, Indiana, 46227, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Crozer-Keystone Regional Cancer Center at Broomall

Broomall, Pennsylvania, 19008, United States
Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
East Jefferson General Hospital

Metairie, Louisiana, 70006, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Forbes Hospital

Monroeville, Pennsylvania, 15146, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Fresno Cancer Center

Fresno, California, 93720, United States
Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095, United States
Geauga Hospital

Chardon, Ohio, 44024, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161, United States
Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States
Good Samaritan Hospital

Corvallis, Oregon, 97330, United States
Grady Health System

Atlanta, Georgia, 30303, United States
Greater Baltimore Medical Center

Baltimore, Maryland, 21204, United States
Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States
Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, 18840, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Helen F Graham Cancer Center

Newark, Delaware, 19713, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States
Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States
IU Health North Hospital

Carmel, Indiana, 46032, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
James J Peters VA Medical Center

The Bronx, New York, 10468, United States
Jefferson Abington Hospital

Abington, Pennsylvania, 19001, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States
Kaiser Permanente Cancer Treatment Center

South San Francisco, California, 94080, United States
Kaiser Permanente Downtown Commons

Sacramento, California, 95814, United States
Kaiser Permanente Dublin

Dublin, California, 94568, United States
Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States
Kaiser Permanente Medical Center-Vacaville

Vacaville, California, 95688, United States
Kaiser Permanente Northwest

Portland, Oregon, 97227, United States
Kaiser Permanente Oakland-Broadway

Oakland, California, 94611, United States
Kaiser Permanente San Leandro

San Leandro, California, 94577, United States
Kaiser Permanente-Deer Valley Medical Center

Antioch, California, 94531, United States
Kaiser Permanente-Fremont

Fremont, California, 94538, United States
Kaiser Permanente-Fresno

Fresno, California, 93720, United States
Kaiser Permanente-Modesto

Modesto, California, 95356, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-Rancho Cordova Cancer Center

Rancho Cordova, California, 95670, United States
Kaiser Permanente-Richmond

Richmond, California, 94801, United States
Kaiser Permanente-Roseville

Roseville, California, 95661, United States
Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States
Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States
Kaiser Permanente-Stockton

Stockton, California, 95210, United States
Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States
Kaiser San Rafael-Gallinas

San Rafael, California, 94903, United States
Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, Michigan, 48910, United States
Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States
Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Lewistown Hospital

Lewistown, Pennsylvania, 17044, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
London Regional Cancer Program

London, Ontario, N6A 4L6, Canada
M D Anderson Cancer Center

Houston, Texas, 77030, United States
Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McLaren Cancer Institute-Bay City

Bay City, Michigan, 48706, United States
McLaren Cancer Institute-Clarkston

Clarkston, Michigan, 48346, United States
McLaren Cancer Institute-Flint

Flint, Michigan, 48532, United States
McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, 48446, United States
McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043, United States
McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, 49770, United States
McLaren-Port Huron

Port Huron, Michigan, 48060, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Hospital North

Colorado Springs, Colorado, 80920, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
Mid-Michigan Physicians-Lansing

Lansing, Michigan, 48912, United States
Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803, United States
New Mexico Oncology Hematology Consultants

Albuquerque, New Mexico, 87109, United States
North Coast Cancer Care

Sandusky, Ohio, 44870, United States
Northwestern University

Chicago, Illinois, 60611, United States
Norton Brownsboro Hospital and Medical Campus

Louisville, Kentucky, 40241, United States
Norton Hospital Pavilion and Medical Campus

Louisville, Kentucky, 40202, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Parkview Hospital Randallia

Fort Wayne, Indiana, 46805, United States
Parkview Regional Medical Center

Fort Wayne, Indiana, 46845, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States
ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rock Hill Radiation Therapy Center

Rock Hill, South Carolina, 29730, United States
Rohnert Park Cancer Center

Rohnert Park, California, 94928, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303, United States
Salina Regional Health Center

Salina, Kansas, 67401, United States
Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Sentara Norfolk General Hospital

Norfolk, Virginia, 23507, United States
Sidney and Lois Eskenazi Hospital

Indianapolis, Indiana, 46202, United States
Singh and Arora Hematology Oncology PC

Flint, Michigan, 48532, United States
Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385, United States
Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital-Hamden Care Center

Hamden, Connecticut, 06518, United States
South Sacramento Cancer Center

Sacramento, California, 95823, United States
Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States
The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, 95678, United States
The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, H3H 2R9, Canada
Torrance Memorial Medical Center

Torrance, California, 90509, United States
Torrance Memorial Physician Network - Cancer Care

Torrance, California, 90505, United States
Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States
UCSF Medical Center-Mount Zion

San Francisco, California, 94115, United States
UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060, United States
UHHS-Westlake Medical Center

Westlake, Ohio, 44145, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States
UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of South Alabama Mitchell Cancer Institute

Mobile, Alabama, 36688, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States
University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States
VA Palo Alto Health Care System

Palo Alto, California, 94304, United States
VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States
Wexford Health and Wellness Pavilion

Wexford, Pennsylvania, 15090, United States
Yale University

New Haven, Connecticut, 06520, United States
Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295, United States

Conditions

Explore the condition pages connected to this study.

CLINICAL STAGE III HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8 HEAD AND NECK SQUAMOUS CELL CARCINOMA HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA LARYNGEAL SQUAMOUS CELL CARCINOMA ORAL CAVITY SQUAMOUS CELL CARCINOMA OROPHARYNGEAL SQUAMOUS CELL CARCINOMA PATHOLOGIC STAGE III HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8 SQUAMOUS CELL CARCINOMA OF UNKNOWN PRIMARY STAGE III HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE III LARYNGEAL CANCER AJCC V8 STAGE III LIP AND ORAL CAVITY CANCER AJCC V8 STAGE III OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IVA HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE IVA LARYNGEAL CANCER AJCC V8 STAGE IVA LIP AND ORAL CAVITY CANCER AJCC V8 STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IVB HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE IVB LARYNGEAL CANCER AJCC V8 STAGE IVB LIP AND ORAL CAVITY CANCER AJCC V8 STAGE IVB OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8