New drug combo could shrink head and neck tumors before surgery
NCT ID NCT06980038
First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 30 times
Summary
This study tests whether adding an experimental drug (CDX-1140) to a standard immunotherapy (cemiplimab) before surgery can shrink tumors more than the immunotherapy alone in people with stage III-IV head and neck cancer. About 44 participants will receive either the combination or the single drug for a short time before their planned surgery. The goal is to see if the combo reduces the amount of tissue that needs to be removed and improves the body's immune response against the cancer.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Emory University Hospital Midtown
RECRUITINGAtlanta, Georgia, 30308, United States
Contact
Contact Phone: •••-•••-••••
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Ochsner Medical Center Jefferson
RECRUITINGNew Orleans, Louisiana, 70121, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITINGIrvine, California, 92612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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VCU Massey Comprehensive Cancer Center
RECRUITINGRichmond, Virginia, 23298, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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