Lung cancer combo trial halted early – only 5 patients tested

NCT ID NCT05141357

Terminated Disease control Sponsor: HUYABIO International, LLC. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a combination of two drugs, HBI-8000 and pembrolizumab (Keytruda), in people with advanced non-small cell lung cancer. The goal was to see if the combination was safe and could shrink tumors. However, the trial was stopped early after enrolling only 5 participants, so we have very little information about how well it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HBI-8000 (tucidinostat) combined with pembrolizumab (Keytruda)
What this could lead to: If it worked, this combination might offer a new treatment option for advanced lung cancer patients who have not had immunotherapy before.
What could go wrong: The trial was terminated early with only 5 participants, so results are very limited. It is unclear if the combination is safe or effective, and it may not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

CBCC Global Research, Inc at Comprehensive Blood and Cancer Center

Bakersfield, California, 93309, United States
Cotton O'Neil Clinical Research Center

Topeka, Kansas, 66606, United States
Frederick Health-JMSCI

Frederick, Maryland, 21702, United States
Hematology Oncology Associates Of The Treasure Coast

Port Saint Lucie, Florida, 34952, United States
Midewestern Regional Medical Center, LLC

Zion, Illinois, 60099, United States
Southeastern Regional Medical Center

Newnan, Georgia, 30265, United States
Western Regional Medical Center

Goodyear, Arizona, 85338, United States

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