New drug GQ1005 takes on T-DM1 in advanced HER2-Positive breast cancer

NCT ID NCT07673029

Recruiting now Disease control Sponsor: GeneQuantum Healthcare (Suzhou) Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether a new drug called GQ1005 works better than the current standard treatment T-DM1 for people with HER2-positive breast cancer that has spread or cannot be removed by surgery. Participants have already been treated with trastuzumab and a taxane. The study measures how long the cancer stays under control and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GQ1005
What this could lead to: If GQ1005 works better than T-DM1, it could offer a new treatment option for people with HER2-positive breast cancer that has spread or cannot be removed by surgery.
What could go wrong: This is a phase 3 trial, but results may not show a clear benefit over the existing drug T-DM1. Side effects of GQ1005 are still being studied and could be similar or different from T-DM1.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HER2-POSITIVE BREAST CANCER

Contacts and locations

Locations

Anhui Cancer Hospital
RECRUITING

Hefei, Anhui, 230031, China
Anyang Cancer Hospital
RECRUITING

Anyang, Henan, 455000, China
Chongqing University Cancer Hospital
RECRUITING

Chongqing, Chongqing Municipality, 400030, China
Deyang People's Hospital
RECRUITING

Deyang, Sichuan, 618000, China
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, 350014, China
Ganzhou Cancer Hospital
RECRUITING

Ganzhou, Jiangxi, 341000, China
Guangxi Medical University Cancer Hospital
RECRUITING

Nanning, Guangxi, 530021, China
Guizhou Medical University Cancer Hospital
RECRUITING

Guiyang, Guizhou, 550004, China
Guizhou Provincial People's Hospital
RECRUITING

Guiyang, Guizhou, 550002, China
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, Heilongjiang, 150081, China
Henan Cancer Hospital
RECRUITING

Zhengzhou, Henan, 450008, China
Hubei Cancer Hospital
RECRUITING

Wuhan, Hubei, 430079, China
Hunan Cancer Hospital
RECRUITING

Changsha, Hunan, 410013, China
Liaoning Cancer Hospital
RECRUITING

Shenyang, Liaoning, 110042, China
Linyi Cancer Hospital
RECRUITING

Linyi, Shandong, 276001, China
Linyi Central Hospital
RECRUITING

Linyi, Shandong, 276003, China
Luoyang Central Hospital
RECRUITING

Luoyang, Henan, 471000, China
Meizhou People's Hospital
RECRUITING

Meizhou, Guangdong, 514011, China
Nanchang People's Hospital
RECRUITING

Nanchang, Jiangxi, 330006, China
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
RECRUITING

Shanghai, Shanghai Municipality, 200127, China
Renmin Hospital of Wuhan University
RECRUITING

Wuhan, Hubei, 430060, China
Shandong Cancer Hospital
RECRUITING

Jinan, Shandong, 250117, China
Shanghai Gaobo Cancer Hospital
RECRUITING

Shanghai, Shanghai Municipality, 201103, China
Shantou Central Hospital
RECRUITING

Shantou, Guangdong, 515031, China
Shanxi Cancer Hospital
RECRUITING

Taiyuan, Shanxi, 30013, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310016, China
Suining Central Hospital
RECRUITING

Suining, Sichuan, 629000, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
RECRUITING

Guangzhou, Guangdong, 510120, China
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, 510060, China
The Affiliated Fuyang Hospital of Anhui Medical University
RECRUITING

Fuyang, Anhui, 236000, China
The Affiliated Hospital of Hebei University
RECRUITING

Baoding, Hebei, 71000, China
The Affiliated Hospital of Hebei University of Engineering
RECRUITING

Handan, Hebei, 56002, China
The Affiliated Hospital of Qingdao University
RECRUITING

Qingdao, Shandong, 266003, China
The Affiliated People's Hospital of Ningbo University
RECRUITING

Ningbo, Zhejiang, 315040, China
The Fifth Medical Center of the Chinese People's Liberation Army General Hospital
RECRUITING

Beijing, Beijing Municipality, 100071, China
The First Affiliated Hospital of Anhui Medical University
RECRUITING

Hefei, Anhui, 230001, China
The First Affiliated Hospital of Bengbu Medical University
RECRUITING

Bengbu, Anhui, 233004, China
The First Affiliated Hospital of China Medical University
RECRUITING

Shenyang, Liaoning, 110001, China
The First Affiliated Hospital of Henan Medical University
RECRUITING

Xinxiang, Henan, 453003, China
The First Affiliated Hospital of Henan University of Science and Technology
RECRUITING

Luoyang, Henan, 471003, China
The First Affiliated Hospital of Jinzhou Medical University
RECRUITING

Jinzhou, Liaoning, 121001, China
The First Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital of Zhengzhou University
RECRUITING

Zhengzhou, Henan, 450052, China
The First Hospital of Jilin University
RECRUITING

Changchun, Jilin, 130021, China
The First People's Hospital of Hangzhou City
RECRUITING

Hangzhou, Zhejiang, 310006, China
The First People's Hospital of Xiaoshan District, Hangzhou City
RECRUITING

Hangzhou, Zhejiang, 311200, China
The Fourth Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Hebei, 50011, China
The Second Affiliated Hospital of Dalian Medical University
RECRUITING

Dalian, Liaoning, 116023, China
The Second Affiliated Hospital of Fujian Medical University
RECRUITING

Quanzhou, Fujian, 362000, China
The Second Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, Shaanxi, 710004, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310009, China
The Second People's Hospital of Liaocheng City
RECRUITING

Linqing, Shandong, 252601, China
The Second People's Hospital of Neijiang City
RECRUITING

Neijiang, Sichuan, 641003, China
The Third People's Hospital of Chengdu City
RECRUITING

Chengdu, Sichuan, 610031, China
Tianjin Cancer Hospital
RECRUITING

Tianjin, Tianjin Municipality, 300060, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430030, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430022, China
Weifang People's Hospital
RECRUITING

Weifang, Shandong, 261041, China
West China Hospital of Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China
Women's Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310006, China
Xingtai People's Hospital
RECRUITING

Xingtai, Hebei, 54001, China
Xuchang Central Hospital
RECRUITING

Xuchang, Henan, 461000, China
Xuzhou Central Hospital
RECRUITING

Xuzhou, Jiangsu, 221009, China
Yantai Yuhuangding Hospital
RECRUITING

Yantai, Shandong, 264000, China
Yidu Central Hospital of Weifang City
RECRUITING

Qingzhou, Shandong, 262500, China
Yongzhou Central Hospital
RECRUITING

Yongzhou, Hunan, 425000, China
Yunnan Cancer Hospital
RECRUITING

Kunming, Yunnan, 650118, China
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, Zhejiang, 310022, China
Zhongnan Hospital of Wuhan University
RECRUITING

Wuhan, Hubei, 430071, China

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