Boosting the Body's army: can a second drug help immune therapy fight deadly melanoma?

NCT ID NCT01134614

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding a drug called GM-CSF (sargramostim) to an existing immune-boosting cancer drug (ipilimumab) could help patients with advanced melanoma live longer. The trial involved 245 adults whose melanoma could not be removed by surgery. Researchers compared the two-drug combination against ipilimumab alone to see which was more effective and safer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Locations

21st Century Oncology-Orange Park

Orange Park, Florida, 32073, United States
AMG Libertyville - Oncology

Libertyville, Illinois, 60048, United States
Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
AdventHealth Porter

Denver, Colorado, 80210, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States
Allegiance Health

Jackson, Michigan, 49201, United States
Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States
Aspirus Cancer Care - James Beck Cancer Center

Rhinelander, Wisconsin, 54501, United States
Aspirus Cancer Care - Stevens Point

Stevens Point, Wisconsin, 54481, United States
Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States
Associates In Womens Health

Wichita, Kansas, 67208, United States
Augusta University Medical Center

Augusta, Georgia, 30912, United States
Aultman Health Foundation

Canton, Ohio, 44710, United States
Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Avera McKennan Hospital and University Health Center

Sioux Falls, South Dakota, 57117-5045, United States
Banner North Colorado Medical Center

Greeley, Colorado, 80631, United States
Banner North Colorado Medical Center - Loveland Campus

Loveland, Colorado, 80539, United States
Bay Area Medical Center

Marinette, Wisconsin, 54143, United States
Baystate Medical Center

Springfield, Massachusetts, 01199, United States
Beacon Kalamazoo

Kalamazoo, Michigan, 49048, United States
Beebe Medical Center

Lewes, Delaware, 19958, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Boca Raton Regional Hospital

Boca Raton, Florida, 33486, United States
Boulder Community Foothills Hospital

Boulder, Colorado, 80303, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010, United States
Cancer Center of Kansas - Chanute

Chanute, Kansas, 66720, United States
Cancer Center of Kansas - Dodge City

Dodge City, Kansas, 67801, United States
Cancer Center of Kansas - El Dorado

El Dorado, Kansas, 67042, United States
Cancer Center of Kansas - Newton

Newton, Kansas, 67114, United States
Cancer Center of Kansas - Parsons

Parsons, Kansas, 67357, United States
Cancer Center of Kansas - Pratt

Pratt, Kansas, 67124, United States
Cancer Center of Kansas - Salina

Salina, Kansas, 67401, United States
Cancer Center of Kansas - Wellington

Wellington, Kansas, 67152, United States
Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States
Cancer Center of Kansas - Winfield

Winfield, Kansas, 67156, United States
Cancer Center of Kansas-Kingman

Kingman, Kansas, 67068, United States
Cancer Center of Kansas-Liberal

Liberal, Kansas, 67905, United States
Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States
Carle BroMenn Medical Center

Normal, Illinois, 61761, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Cancer Institute Normal

Normal, Illinois, 61761, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Christiana Care - Union Hospital

Elkton, Maryland, 21921, United States
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cleveland Clinic Mercy Hospital

Canton, Ohio, 44708, United States
Community Howard Regional Health

Kokomo, Indiana, 46904, United States
Cooper Hospital University Medical Center

Camden, New Jersey, 08103, United States
Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States
Creighton University Medical Center

Omaha, Nebraska, 68131, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Doylestown Hospital

Doylestown, Pennsylvania, 18901, United States
DuPage Medical Group-Ogden

Naperville, Illinois, 60563, United States
Duly Health and Care Joliet

Joliet, Illinois, 60435, United States
Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut, 06360, United States
Eisenhower Medical Center

Rancho Mirage, California, 92270, United States
Elkhart General Hospital

Elkhart, Indiana, 46515, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Erlanger Medical Center

Chattanooga, Tennessee, 37403, United States
Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States
Essentia Health Saint Mary's Medical Center

Duluth, Minnesota, 55805, United States
Eureka Hospital

Eureka, Illinois, 61530, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Franciscan Saint Anthony Health-Michigan City

Michigan City, Indiana, 46360, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Center-Cancer Center Hazleton

Hazleton, Pennsylvania, 18201, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Genesys Regional Medical Center-West Flint Campus

Flint, Michigan, 48532, United States
Graham Hospital Association

Canton, Illinois, 61520, United States
Greater Baltimore Medical Center

Baltimore, Maryland, 21204, United States
Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States
Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, 18840, United States
HSHS Saint Nicholas Hospital

Sheboygan, Wisconsin, 53081, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Heartland Cancer Research NCORP

Decatur, Illinois, 62526, United States
Hematology Oncology Associates of Illinois - Skokie

Skokie, Illinois, 60076, United States
Hematology Oncology Associates of Illinois-Highland Park

Highland Park, Illinois, 60035, United States
Hematology and Oncology Associates

Chicago, Illinois, 60611, United States
Hematology and Oncology Associates of North East Pennsylvania

Scranton, Pennsylvania, 18508, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States
Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States
Hinsdale Hematology Oncology Associates Incorporated

Hinsdale, Illinois, 60521, United States
Holy Family Memorial Hospital

Manitowoc, Wisconsin, 54221, United States
Hunterdon Medical Center

Flemington, New Jersey, 08822, United States
Hurley Medical Center

Flint, Michigan, 48503, United States
Hutchinson Area Health Care

Hutchinson, Minnesota, 55350, United States
IU Health Ball Memorial Hospital

Muncie, Indiana, 47303, United States
IU Health La Porte Hospital

La Porte, Indiana, 46350, United States
Illinois Cancer Specialists-Niles

Niles, Illinois, 60714, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois Valley Hospital

Peru, Illinois, 61354, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Intermountain Health Lutheran Hospital

Wheat Ridge, Colorado, 80401, United States
Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Iowa-Wide Oncology Research Coalition NCORP

Des Moines, Iowa, 50309, United States
Jackson-Madison County General Hospital

Jackson, Tennessee, 38301, United States
Jefferson Abington Hospital

Abington, Pennsylvania, 19001, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Lake Huron Medical Center

Port Huron, Michigan, 48060, United States
Lakeland Regional Health Hollis Cancer Center

Lakeland, Florida, 33805, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
MacNeal Hospital and Cancer Center

Berwyn, Illinois, 60402, United States
Manchester Memorial Hospital

Manchester, Connecticut, 06040, United States
Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States
Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin, 54701, United States
Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States
Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Mary Imogene Bassett Hospital

Cooperstown, New York, 13326, United States
Mason District Hospital

Havana, Illinois, 62644, United States
Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States
McFarland Clinic - Ames

Ames, Iowa, 50010, United States
Mcdonough District Hospital

Macomb, Illinois, 61455, United States
Medical X-Ray Center

Sioux Falls, South Dakota, 57105, United States
Memorial Hospital

Carthage, Illinois, 62321, United States
Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States
Mercy Health - Saint Vincent Hospital

Toledo, Ohio, 43608, United States
Mercy Hospital

Cedar Rapids, Iowa, 52403, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center - North Iowa

Mason City, Iowa, 50401, United States
Mercy Medical Center-Sioux City

Sioux City, Iowa, 51102, United States
Mercyhealth Hospital and Cancer Center - Janesville

Janesville, Wisconsin, 53548, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Metro Minnesota Community Oncology Research Consortium

Saint Louis Park, Minnesota, 55416, United States
MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
Michigan Cancer Research Consortium NCORP

Ann Arbor, Michigan, 48106, United States
Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Morristown Medical Center

Morristown, New Jersey, 07960, United States
MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States
Nebraska Cancer Research Center

Lincoln, Nebraska, 68510, United States
Nevada Cancer Institute-Summerlin Campus

Las Vegas, Nevada, 89135, United States
Nevada Cancer Research Foundation NCORP

Las Vegas, Nevada, 89120, United States
New York Oncology Hematology PC - Albany Medical Center

Albany, New York, 12208, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
North Suburban Medical Center

Thornton, Colorado, 80229, United States
Northern Indiana Cancer Research Consortium

South Bend, Indiana, 46628, United States
Northwestern University

Chicago, Illinois, 60611, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Pekin

Pekin, Illinois, 61554, United States
OSF Saint Joseph Medical Center

Bloomington, Illinois, 61701, United States
Ochsner Health Center-Covington

Covington, Louisiana, 70433, United States
Ochsner Health Center-Summa

Baton Rouge, Louisiana, 70809, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa, 52403, United States
Ottawa Regional Hospital and Healthcare Center

Ottawa, Illinois, 61350, United States
Overlook Hospital

Summit, New Jersey, 07902, United States
Owensboro Health Mitchell Memorial Cancer Center

Owensboro, Kentucky, 42303, United States
Paoli Memorial Hospital

Paoli, Pennsylvania, 19301, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parkland Memorial Hospital

Dallas, Texas, 75235, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Perry Memorial Hospital

Princeton, Illinois, 61356, United States
Pottstown Hospital

Pottstown, Pennsylvania, 19464, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States
Presbyterian Kaseman Hospital

Albuquerque, New Mexico, 87110, United States
Presence Saint Mary's Hospital

Kankakee, Illinois, 60901, United States
ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States
ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States
ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, 43606, United States
Proctor Hospital

Peoria, Illinois, 61614, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Rose Medical Center

Denver, Colorado, 80220, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
Rush-Copley Medical Center

Aurora, Illinois, 60504, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
SSM Health Dean Medical Group - South Madison Campus

Madison, Wisconsin, 53715, United States
Saint Anthony Hospital

Lakewood, Colorado, 80228, United States
Saint Charles Hospital

Oregon, Ohio, 43616, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Hospital - Cancer Centers of Colorado

Denver, Colorado, 80218, United States
Saint Joseph Regional Medical Center-Mishawaka

Mishawaka, Indiana, 46545, United States
Saint Luke's Regional Medical Center

Sioux City, Iowa, 51104, United States
Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, Pennsylvania, 18015, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Mary Medical and Regional Cancer Center

Langhorne, Pennsylvania, 19047, United States
Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501, United States
Saint Rita's Medical Center

Lima, Ohio, 45801, United States
Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States
San Juan Oncology Associates

Farmington, New Mexico, 87401, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Siouxland Regional Cancer Center

Sioux City, Iowa, 51101, United States
Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States
Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Summa Health System - Akron Campus

Akron, Ohio, 44304, United States
Swedish American Hospital

Rockford, Illinois, 61104, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
The Christ Hospital

Cincinnati, Ohio, 45219, United States
The Hospital of Central Connecticut

New Britain, Connecticut, 06050, United States
The Medical Center of Aurora

Aurora, Colorado, 80012, United States
ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
Trinity Medical Center

Moline, Illinois, 61265, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
UW Health Carbone Cancer Center Rockford

Rockford, Illinois, 61114, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Cancer and Blood Center LLC

Athens, Georgia, 30607, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States
VA Palo Alto Health Care System

Palo Alto, California, 94304, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States
Virtua Memorial

Mount Holly, New Jersey, 08060, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
West Virginia University Charleston Division

Charleston, West Virginia, 25304, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Western States Cancer Research NCORP

Denver, Colorado, 80222, United States
Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003, United States
Wichita NCI Community Oncology Research Program

Wichita, Kansas, 67214, United States
Yale University

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED MELANOMA METASTATIC MELANOMA RECURRENT MELANOMA STAGE III CUTANEOUS MELANOMA AJCC V7 STAGE IIIA CUTANEOUS MELANOMA AJCC V7 STAGE IIIB CUTANEOUS MELANOMA AJCC V7 STAGE IIIC CUTANEOUS MELANOMA AJCC V7 STAGE IV CUTANEOUS MELANOMA AJCC V6 AND V7 UNRESECTABLE MELANOMA