Brain fuel mystery: Glucagon's role in thinking and sugar

NCT ID NCT06921824

Completed Knowledge-focused Sponsor: Nicolai Jacob Wewer Albrechtsen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study looked at how the hormone glucagon affects brain function and sugar use in 16 healthy adults. Participants received a gradually increasing dose of glucagon through an IV over three hours. The goal was to find the dose that changes blood sugar and other markers, helping researchers understand glucagon's role in the brain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Glucagon
What this could lead to: If successful, this could help scientists understand how glucagon affects the brain and sugar use, possibly pointing toward new treatments for metabolic or cognitive disorders.
What could go wrong: This is a very small, early pilot study in healthy people, not patients. It only looks at short-term effects, so results may not apply to real-world conditions or lead to any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glucose metabolism disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLUCAGON GLUCOSE METABOLISM

Contacts and locations

Locations

Department of Clinical Biochemistry, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

Copenhagen, 2400, Denmark

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