Glowing dye could help surgeons spot hidden brain tumor cells

NCT ID NCT04305470

Completed Diagnosis Sponsor: NX Development Corp Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 3 trial tested a drug called Gleolan in 108 adults with meningioma (a type of brain tumor). Patients took a single oral dose before surgery. The drug makes tumor tissue glow under special light, helping surgeons see and remove more of the tumor. The study checked if the glowing areas matched lab results for tumor tissue.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gleolan (aminolevulinic acid hydrochloride)
What this could lead to: If successful, Gleolan could help surgeons more completely remove meningiomas by making tumor tissue glow during surgery.
What could go wrong: This is a single-arm study with no placebo group, so results may be less definitive. The drug may not work for all tumor types or locations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

meningioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENINGIOMA

Contacts and locations

Locations

Baptist Health South Florida

Miami, Florida, 33176, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
Keck Hospital of USC

Los Angeles, California, 90033, United States
MD Anderson

Houston, Texas, 77030, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Phoenix, Arizona, 85054, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Medical University of Vienna

Vienna, 1090, Austria
NYU Langone Health

Brooklyn, New York, 11220, United States
Providence St. Joseph Hospital

Orange, California, 92868, United States
Southern Illinois University

Springfield, Illinois, 62702, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
UPMC

Pittsburgh, Pennsylvania, 15213, United States
University Hospital Münster

Münster, Germany
University of California San Diego

La Jolla, California, 92093, United States
University of Miami

Coral Gables, Florida, 33136, United States
University of Pennsylvania- Penn Medicine

Philadelphia, Pennsylvania, 19104, United States

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