New drug cocktail targets Hard-to-Treat cancers
NCT ID NCT07318649
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 study tests two oral drugs, GH21 and D-1553, in 120 adults with advanced solid tumors that have a specific mutation called KRASG12C. Participants have already tried other treatments without success. The goal is to see if the combination can shrink tumors and control the disease. The study is not yet recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- GH21 capsules and D-1553 tablets
- What this could lead to
- If successful, this combination could offer a new treatment option for people with KRASG12C-mutated cancers that have stopped responding to other therapies.
- What could go wrong
- This is an early Phase 2 trial with only 120 participants, so results may not apply to everyone. The drugs may cause side effects or fail to shrink tumors in many patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
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Other studies related to the condition(s) this trial covers.
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