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Can blocking knee blood vessels ease arthritis pain without surgery?

NCT ID NCT07807943

Symptom relief Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This study looks at whether geniculate artery embolization, a procedure that blocks blood flow to the knee, can reduce pain and improve function in cancer survivors with knee osteoarthritis. Participants are adults aged 40 and older with chronic knee pain who have not found relief from standard treatments and are not good candidates for or have refused knee replacement surgery. Researchers will track pain levels and quality of life over time to see if the procedure helps this specific group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Geniculate artery embolization, a procedure that blocks blood flow to the knee to reduce pain and inflammation
What this could lead to
If it works, this could offer cancer survivors with knee osteoarthritis a non-surgical option to reduce pain and improve mobility, potentially avoiding the need for knee replacement surgery.
What could go wrong
This is an observational study, so it will not prove the procedure works. The procedure carries risks like pain, swelling, or damage to nearby tissues, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Jun 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

UT MD Anderson Cancer Center

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Age ≥40 years with no upper age restriction, provided performance status permits procedural candidacy 2. Symptomatic mild-to-severe knee osteoarthritis (Kellgren-Lawrence grade 2-4) on radiographs within 6 months of enrollment 3. Chronic knee pain (NRS ≥4/10) for ≥3 months despite conservative treatment including steroid injections, physical therapy, and/or analgesic medications 4. Inadequate candidate for or refusal of surgical intervention (e.g., total knee arthroplasty) due to cancer-related comorbidities, ongoing treatment, or participants preference 5. Active cancer diagnosis (solid tumor or hematologic malignancy) confirmed at MD Anderson Cancer Center Exclusion Criteria * Active joint infection or suspected septic arthritis * Life expectancy \<6 months * Prior knee arthroplasty in the index knee * Coagulopathy or contraindications to angiography * GFR \<30 mL/min/1.73m² * Peripheral artery disease with stenosis or occlusion of lower extremity vasculature (relative contraindication per SIR standards, given geniculate artery collateral perfusion role) * Radiographically normal knee joint (KL grade 0-1) - alternative etiologies should be sought * Known active autoimmune/inflammatory arthropathy (e.g., rheumatoid arthritis, psoriatic arthritis) * Any medical condition or clinical abnormality that, per investigator judgment, precludes safe participation in and completion of the study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Embolization Geniculate artery Observational study Symptomatic knee osteoarthritis

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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Contacts and locations

Locations

  • UT MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77044, United States

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